Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC

Baba, Masataka; Imai, Toshio; Nishimura, Miyuki; Kakizaki, Mayumi; Takagi, Shin; Hieshima, Kunio; Nomiyama, Hisayuki; Yoshie, Osamu

doi:10.1074/jbc.272.23.14893

Cited by 375 publications

(272 citation statements)

References 47 publications

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“…IL-2 has been described to potently up-regulate CCR1, CCR2, CCR5, CCR6, and CXCR3 (27,30,32,50,51). More recently, IL-15 has been shown to have similar effects on some of the CC chemokine receptors (27,33).…”

Section: Discussionmentioning

confidence: 99%

The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse

Unutmaz

Xiang

Sunshine

et al. 2000

The Journal of Immunology

192

157

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Chemokines play necessary and important roles in regulating the trafficking of lymphocytes to intra- or interlymphoid tissues as well as to sites of inflammation. The complex migratory patterns of lymphoid lineage cells is governed by subset-specific expression of chemokine receptors and their access to specific ligands. Several chemokine receptors and chemokine receptor-like orphan receptors also serve, in conjunction with CD4, as coreceptors for infection by human and simian immunodeficiency viruses (HIV and SIV). Here we show that the expression pattern of Bonzo/STRL33, an orphan SIV/HIV coreceptor, is highly restricted to the memory subset of T cells and is up-regulated upon stimulation of these cells with IL-2 or IL-15. Both the pattern and the regulation of Bonzo expression closely paralleled that of CC family chemokine receptors CCR5 or CCR6 and inversely correlated with CXCR4 expression. However, in striking contrast to CCR5, Bonzo expression was not down-modulated by PMA or mitogen stimulation of T cells. Targeted replacement of the Bonzo gene with a gene encoding green fluorescent protein in mice revealed that the expression and cytokine regulation of mouse Bonzo are comparable to those of its human counterpart. The similar expression and regulation patterns of Bonzo and the HIV coreceptor CCR5 may have implications for understanding the role of HIV/SIV receptors in viral evolution and pathogenesis.

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Section: Discussionmentioning

confidence: 99%

The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse

Unutmaz

Xiang

Sunshine

et al. 2000

The Journal of Immunology

192

157

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“…CCR5 can bind to other CC chemokines (CCL2, CCL7-8 and CCL13) with decreased affinity [61]. CCR6 has been shown to be a receptor for CCL20 [62]. CCL19 and CCL21 bind to CCR7 [63] while CCR8 appears to bind CCL1 specifically [64].…”

Section: Chemokinesmentioning

confidence: 99%

Chemokines in tumor angiogenesis and metastasis

Singh

Sadanandam

Singh

2007

Cancer Metastasis Rev

158

132

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Chemokines are a large group of low molecular weight cytokines that are known to selectively attract and activate different cell types. Although the primary function of chemokines is well recognized as leukocyte attractants, recent evidences indicate that they also play a role in number of tumor-related processes, such as growth, angiogenesis and metastasis. Chemokines activate cells through cell surface seven trans-membranes, G-protein-coupled receptors (GPCR). The role played by chemokines and their receptors in tumor pathophysiology is complex as some chemokines favor tumor growth and metastasis, while others may enhance anti-tumor immunity. These diverse functions of chemokines establish them as key mediators between the tumor cells and their microenvironment and play critical role in tumor progression and metastasis. In this review, we present some of the recent advances in chemokine research with special emphasis on its role in tumor angiogenesis and metastasis.

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“…Activated T cells express CXCR3 [69,70], CXCR4 [71], CCR1 [72], CCR2 [72,73], CCR3 [70,74], CCR4 [71,74], CCR5 [70,73,75], CCR6 [76], CCR7 [77,78], and CCR8 [79][80][81] (Table 4). Activated T cells can be polarized to either T helper (Th) 1 or Th2 type cells, which demonstrate differential profiles of cytokine expression and helper functions in immune reaction.…”

Section: Chemokines For Activated or Memory Lymphocytesmentioning

confidence: 99%

Chemokines: signal lamps for trafficking of T and B cells for development and effector function

Kim

Broxmeyer

1999

Journal of Leukocyte Biology

327

251

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Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC

Abstract: ؉ and CD8 ؉ T cells was strongly up-regulated by IL-2. Taken together, GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-CY4. We propose GPR-CY4 to be designated as CCR6.

Cited by 375 publications

References 47 publications

The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse

The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse

Chemokines in tumor angiogenesis and metastasis

Chemokines: signal lamps for trafficking of T and B cells for development and effector function

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