Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach

Anda-Jáuregui, Guillermo de; Espinal-Enríquez, Jesús; Hur, Junguk; Alcalá-Corona, Sergio Antonio; Ruíz-Azuara, Lena; Hernández‐Lemus, Enrique

doi:10.1016/j.compbiolchem.2018.11.021

Cited by 12 publications

(9 citation statements)

References 62 publications

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“…The molecular design allows varying their lipophilicity and cellular accumulation. The results obtained together with the promising data obtained for elesclomol L13 [38] confirm the promising use of copper coordination compounds in treating bacterial pneumonia caused by Mtb. The therapy certainly owes its success to the redox activity of copper cations.…”

Section: Drug-based Copper Coordination Compoundssupporting

confidence: 71%

“…Guillermo de Anda-Jáuregui et al recently constructed a network with deregulated biological pathways featuring links between pathways that crosstalk with each other. Through this approach, the following three features of Casiopeina treatment were identified: (a) perturbation of signaling pathways related to apoptosis induction, (b) perturbation of metabolic pathways, and (c) activation of immune responses [38].…”

Section: N-and O-donor Ligandsmentioning

confidence: 99%

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Copper Coordination Compounds as Biologically Active Agents

Krasnovskaya

Naumov

Guk

et al. 2020

IJMS

121

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Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordination compounds are effective antitumor agents, constituting a less expensive and safer alternative to classical platinum-containing chemotherapy, and are also effective as antimicrobial, antituberculosis, antimalarial, antifugal, and anti-inflammatory drugs. 64Cu-labeled coordination compounds are promising PET imaging agents for diagnosing malignant pathologies, including head and neck cancer, as well as the hallmark of Alzheimer’s disease amyloid-β (Aβ). In this review article, we summarize different strategies for possible use of coordination compounds in the treatment and diagnosis of various diseases, and also various studies of the mechanisms of antitumor and antimicrobial action.

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Section: Drug-based Copper Coordination Compoundssupporting

confidence: 71%

Section: N-and O-donor Ligandsmentioning

confidence: 99%

Copper Coordination Compounds as Biologically Active Agents

Krasnovskaya

Naumov

Guk

et al. 2020

IJMS

121

View full text Add to dashboard Cite

show abstract

“…For instance, the Cu 2+ complex named Casiopeína IIgly is being studied as a potential new anticancer drug. It induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction, ultimately resulting in apoptosis [108,109]. Also, Slator and coworkers [110] investigated the Cu 2+ complex [Cu(o-phthalate)(phenanthroline)] as an intracellular ROS-active cytotoxic agent [110].…”

Section: Advancing Melanoma Systemic Treatment—potential Targets Amentioning

confidence: 99%

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

2019

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Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the lack of efficacy in advanced stages of the disease have demanded the search for novel bioactive molecules and/or efficient drug delivery systems. The current review aims to discuss the most recent advances on the elucidation of potential targets for melanoma treatment, such as aquaporin-3 and tyrosinase. In addition, the role of nanotechnology as a valuable strategy to effectively deliver selective drugs is emphasized, either incorporating/encapsulating synthetic molecules or natural-derived compounds in lipid-based nanosystems such as liposomes. Nanoformulated compounds have been explored for their improved anticancer activity against melanoma and promising results have been obtained. Indeed, they displayed improved physicochemical properties and higher accumulation in tumoral tissues, which potentiated the efficacy of the compounds in pre-clinical experiments. Overall, these experiments opened new doors for the discovery and development of more effective drug formulations for melanoma treatment.

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“…Similarly, Cas III-ia, besides showing a dose-dependent antiproliferative activity in different tumor cell lines, can also decrease migration in the neuroblastoma cell line SK-N-SH [86]. Furthermore, the expression of genes induced by Cas II-gly treatment were studied in HeLa cells, demonstrating that this compound can decrease the expression of migration-related genes, such as: TGFbR1, AURKA, SNAI2, BMP4, BMP6, and N-CADHERIN [42,[86][87][88]. Cas II-gly was also shown to act on MALAT1, targeting miR-17-5p to inhibit FZD2 expression by inactivating the Wnt signaling pathway, thus inhibiting cell proliferation and promoting apoptosis in HeLa and CaSki cells [89].…”

Section: Proposed Mechanisms Of Actionmentioning

confidence: 99%

Metallodrugs: an approach against invasion and metastasis in cancer treatment

2022

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Cancer is a heterogeneous and multifactorial disease that causes high mortality throughout the world; therefore, finding the most effective therapies is a major research challenge. Currently, most anticancer drugs present a limited number of well‐established targets, such as cell proliferation or death; however, it is important to consider that the worse progression of cancer toward pathological stages implies invasion and metastasis processes. Medicinal Inorganic Chemistry (MIC) is a young area that deals with the design, synthesis, characterization, preclinical evaluation, and mechanism of action of new inorganic compounds, called metallodrugs. The properties of metallic ions allow enriching of strategies for the design of new drugs, enabling the adjustment of physicochemical and stereochemical properties. Metallodrugs can adopt geometries, such as tetrahedral, octahedral, square planar, and square planar pyramid, which adjusts their arrangement and facilitates binding with a wide variety of targets. The redox properties of some metal ions can be modulated by the presence of the bound ligands to adjust their interaction, thereby opening a range of mechanisms of action. In this regard, the mechanisms of action that trigger the biological activity of metallodrugs have been generally identified by: (a) coordination of the metal to biomolecules (for instance, cisplatin binds to the N7 in DNA guanine, as Pt‐N via coordination of the inhibition of enzymes); (b) redox‐active; and (c) ROS production. For this reason, a series of metallodrugs can interact with several specific targets in the anti‐invasive processes of cancer and can prevent metastasis. The structural base of several metal compounds shows great anticancer potential by inhibiting the signaling pathways related to cancer progression. In this minireview, we present the advances in the field of antimetastatic effects of metallodrugs.

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Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach

Cited by 12 publications

References 62 publications

Copper Coordination Compounds as Biologically Active Agents

Copper Coordination Compounds as Biologically Active Agents

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

Metallodrugs: an approach against invasion and metastasis in cancer treatment

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