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“…These results were in agreement with the conclusions of previous structure-activity relationship investigations by other researchers. [5][6][7]11,15) It was proved that the protein-ligands binding mechanism could be used as a mode to elucidate the biological and pharmacological properties of the ligands. In addition, once the carboxyl groups being esterified, the binding affinities became stronger, which suggested that esterification of carboxyl group also seemed having some effects in the interaction processes.…”
Section: Resultsmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…These results were in agreement with the conclusions of previous structure-activity relationship investigations by other researchers. [5][6][7]11,15) It was proved that the protein-ligands binding mechanism could be used as a mode to elucidate the biological and pharmacological properties of the ligands. In addition, once the carboxyl groups being esterified, the binding affinities became stronger, which suggested that esterification of carboxyl group also seemed having some effects in the interaction processes.…”
Section: Resultsmentioning
“…Most important, CQAs have been established as an important class of compounds with their potential effects of inhibiting human immunodeficiency virus (HIV)-1 integrase selectively and preventing HIV-1 replication in tissue culture at nontoxic concentrations. [12][13][14] Structure-activity relationship studies showed that their antioxidant, 5) antitumor, 6) hepatoprotective 7) and antimutagenicity 11) activities increased in proportion to the number of caffeoyl groups. Recently, it was also concluded that the radical scavenging activity of natural dicaffeoylquinic acids in the biological aqueous system might depend on the positions of caffeoyl ester groups.…”
mentioning
“…[1][2][3] CQA derivatives have a variety of bioactivities such as antioxidant, antibacterial, anticancer, antihistamic, and other biological effects. [4][5][6][7][8] In our previous study, we demonstrated that 3,5-di-O-caffeoylquinic acid (3,5-di-CQA) inhibits amyloid b 1-42 -induced cellular toxicity on human neuroblastoma SH-SY5Y cells, and increases the mRNA expression level of glycolytic enzyme, phosphoglycerate kinase 1 (PGK1) and the intracellular ATP level. 9) We also indicated that 3,5-di-CQA administration induced the improvement of spatial learning and memory on senescence accelerated-prone mice 8 (SAMP8), and the overexpression of PGK1 mRNA level.…”
mentioning
“…Human myeloid leukemia cells, specifically HL-60 cells, are known to differentiate into granulocytes or monocytes when treated with a variety of compounds, such as all-transretinoic acid (ATRA), dimethyl sulfoxide and vitamin D3 (13,14). In particular, ATRA is a class of chemical compounds that are structurally related to vitamin A; ATRA is one class of compounds known as retinoids, which are used for clinical therapy for acute promyelocytic leukemia (APL) (13).…”
Section: Introductionmentioning