PLoS ONE volume 9, issue 6, Pe98408 2014 DOI: 10.1371/journal.pone.0098408 View full text
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Keith H. Jansson, Deborah G. Castillo, Joseph W. Morris, Mary E. Boggs, Kirk J. Czymmek, Elizabeth L. Adams, Lawrence P. Schramm, Robert A. Sikes

Abstract: Prostate cancer (PCa) is believed to metastasize through the blood/lymphatics systems; however, PCa may utilize the extensive innervation of the prostate for glandular egress. The interaction of PCa and its nerve fibers is observed in 80% of PCa and is termed perineural invasion (PNI). PCa cells have been observed traveling through the endoneurium of nerves, although the underlying mechanisms have not been elucidated. Voltage sensitive sodium channels (VSSC) are multimeric transmembrane protein complexes compr…

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