2006
DOI: 10.1089/scd.2006.15.407
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Abstract: Multipotent neural stem/progenitor cells (NSPCs) can be isolated from many regions of the adult central nervous system (CNS), yet neurogenesis is restricted to the hippocampus and subventricular zone in vivo. Identification of the molecular cues that modulate NSPC fate choice is a prerequisite for their therapeutic applications. We previously demonstrated that primary astrocytes isolated from regions with higher neuroplasticity, such as newborn and adult hippocampus and newborn spinal cord, promoted neuronal d… Show more

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Cited by 266 publications
(252 citation statements)
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“…Here, we found that, where the two types of process met on the surface of the blood vessel, their membranes were of complementary thicknesses, and adhesion points existed between them. Astrocyte-expressed factors, such as Wnt3a, interleukins IL-1β and IL6, and ATP, promote differentiation of neural stem progenitor cells, whereas growth factor binding protein IGFBP6 and proteoglycan decorin inhibit their differentiation (98)(99)(100). Astrocyte-stem cell interactions have also been shown to regulate neurogenesis by secretion of ephrin-B2, which activates EphB4 receptors on the stem cell (101).…”
Section: Discussionmentioning
confidence: 99%
“…Here, we found that, where the two types of process met on the surface of the blood vessel, their membranes were of complementary thicknesses, and adhesion points existed between them. Astrocyte-expressed factors, such as Wnt3a, interleukins IL-1β and IL6, and ATP, promote differentiation of neural stem progenitor cells, whereas growth factor binding protein IGFBP6 and proteoglycan decorin inhibit their differentiation (98)(99)(100). Astrocyte-stem cell interactions have also been shown to regulate neurogenesis by secretion of ephrin-B2, which activates EphB4 receptors on the stem cell (101).…”
Section: Discussionmentioning
confidence: 99%
“…pCMV-Tag2B-EENA1 ∆BAR (∆ aa 6-242), pCMV-Tag2B-EE-NA1 ∆SH3 ( aa 295-346), pCMV-Tag2B-EENA1 KKK-EEE (mutation K171, K172 and K173 to E), pCMV-Tag2B-EENA1 BAR-∆H1I (∆ aa 1-32 and aa 59-87) and the point mutant constructs of endophilin A1 (299 301 308 327 340 343), were created by site-directed mutagenesis using pCMV-Tag2B-EENA1 as template. EENA1-LentiGFP construct was generated by insertion of mouse EENA1 into the SfiI restriction site of a lenti GFP vector, a generous gift from Dr Xinyu Zhao (University of Wisconsin-Madison School of Medicine and Public Health, Madison, USA [41,42]). The shRNA-resistant endophilin A1 expression construct was generated by modifying 5′-GGACTCATTGGACATG-GAA-3′ (nt 384-402 of mouse endophilin A1 coding region) into 5′-GGACTCTCTTGACATGGAA-3′ by site-directed mutagenesis.…”
Section: Constructsmentioning
confidence: 99%
“…In both the SVZ and SGZ, the neurogenic niche consists of endothelial cells and astrocytes. Endothelial cells promote the self-renewal of NSCs by releasing vascular-derived factors (VEGFs) (Jin et al 2002;Cao et al 2004), whereas astrocytes direct NSCs to differentiate by releasing Wnt3, IL-1b, and IL-6 (Lie et al 2005;Barkho et al 2006). Differentiated neurons can also participate in the feedback regulation of stem cell fate by releasing neurotransmitters such as GABA (Ge et al 2006).…”
Section: Adult Neurogenesismentioning
confidence: 99%