Identification of a small molecule activator of SIRT1 gene expression

Cho, Si Young; Cho, Miook; Seo, Dae Shik; Lee, Sang Yup; Suh, Yousin

doi:10.18632/aging.100539

Cited by 25 publications

(16 citation statements)

References 12 publications

(14 reference statements)

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“…In the future, we will test whether administration of antibiotics could abolish the effect of SYR on immune and endocrine system in the SPF mice. In addition, given the fact that SIRT1 and FOXO3 participate in the regulation of glucose metabolism and Treg homeostasis467475, and SYR induces the activation of SIRT1 and FOXO331 (Fig. 3), still there is a possibility that SYR may have a direct effect on the level of blood glucose as well as Treg homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…However, to our knowledge, there have been no reports regarding SYR metabolism by gut microbiota and the effects of SYR on modulation of the gut microbiota. Recently, we demonstrated that SYR delays cellular senescence and alleviates hypoxia/reoxygenation injury through the activation of FOXO33031. SYR stimulated the nuclear translocation of FOXO3, leading to the transcriptional activation of its target genes involved in the antioxidant and anti-inflammatory effects30.…”

mentioning

confidence: 99%

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

Cho

Kim

Lee

et al. 2016

Sci RepHas erratum 2017-1-31 Has correction 2017-1-31

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Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and the gut microbiota associated with this effect in middle-aged mice. Compared with age-matched control mice, SYR treatment delayed immunosenescence by enhancing the numbers of total CD3+ T cells and naïve T cells. SYR treatment induced the expression of Bim as well as activation of FOXO3 in Foxp3+ regulatory T cells (Tregs). Furthermore, SYR treatment significantly enhanced the Firmicutes/Bacteroidetes ratio compared with that in age-matched controls by increasing beneficial bacteria, Lactobacillus and Bifidobacterium, while reducing the opportunistic pathogenic genus, Akkermansia. In addition, SYR treatment reduced the serum level of lipopolysaccharide-binding protein, an inflammatory marker, and enhanced humoral immunity against influenza vaccination to the level of young control mice. Taken together, these findings suggest that SYR may rejuvenate the immune system through modulation of gut integrity and microbiota diversity as well as composition in middle-aged mice, which may delay the immunosenescence associated with aging.

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“…For example, increase of dSir2 transcription is observed in the long-lived mutant flies and calorierestricted normal flies [60]. It was found, that pharmacological agents resveratrol [61], polydatin [62], syringaresinol [63], and phloridzin [64], which are known to have anti-aging effect and relive senescence-associated patologies, induces expression of the SIRT1 homologues too.…”

Section: Discussionmentioning

confidence: 99%

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Lashmanova

Proshkina

Zhikrivetskaya

et al. 2015

Pharmacological Research

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“…Interestingly, ginsenoside-free molecules promote ethanol metabolism [127]. Recently, a lignin compound, syringaresinol(4,4'-(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-a,4-diylbis(2,6-dimethoxyphenol)), was isolated from panax ginseng pulp and found to activate SIRT1 gene expression, leading to delayed cellular senescence and improved endothelial cell function in endothelial cells [128]. Syringaresinol treatment induced the binding of FOXO3 to the SIRT1 promoter in a sequence-specific manner, leading to the induction of SIRT1 expression.…”

Section: Exploring Other Bioactive Constituents In the Ginseng Berry mentioning

confidence: 99%

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

Kim¹,

Cho²,

Kim³

et al. 2016

JARB

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Journal of Advanced Research in Biotechnology Open Access Review Article Introduction: Ginseng and the Ginseng berryGinseng (Panax ginseng) is a popular herbal medicine that has been used in Asia for 5,000 years [1]. Ginseng is classified as fresh, white, or red ginseng, depending on the processing method. As a traditional herb, red ginseng is known as an adaptogen that restores and improves normal well-being. The use of this herbal plant has been widespread throughout the world because of its therapeutic effects. The well-known biochemical and pharmacological effects include anti-cancer [2], anti-fatigue [3], and anti-diabetic effects [4], along with promoting the synthesis of DNA, RNA and proteins [5]. The herb is used as a tea, an extract, or raw directly from powdered root [6]. The representative bioactive compounds are widely considered to begin senosides, which are ginseng-specific saponins [7]. Currently, more than 100 naturally occurring saponins of various types and products of enzymatic conversion have been isolated from the roots, stems, leaves, flowers, berries, and seeds of ginseng. The different parts of ginseng contain distinct ginsenoside profiles, and thus, different parts probably possess different pharmacological effects [8].Recently, many health reports have recommended an increase in fruit intake as part of a healthy dietary pattern [9,10]. These reports allow for various forms of fruit, including fresh, frozen, and dried, as well as juices, and recommend fruits such as oranges, apples, bananas, grapes, raisins, and berries. Whereas berries are known as a good source of potassium or fiber, recent studies suggest that berry fruits are a rich source of many phytochemicals that have a broad spectrum of bioactivity and a positive impact on general health. Several berry fruits, including blackberries, blueberries, cranberries, raspberries, and strawberries, have recently received attention as a result of their effects in vitro and their associations with lowered risks for some chronic diseases, which were found in recent observational research [11,12]. As a perennial herb, ginseng develops flowers and fruits that bloom in its third and fourth year. Unlike the widely used ginseng root, the ginseng berry is preserved for planting and has not been used by general populations. A recent study reported that the ginseng leaf and berry have higher levels of ginsenosides than ginseng root, and their pharmacological activities have also been reported [13]. In this review, we will summarize the research on the role of dietary ginseng berries in delaying aging, as well as evidence suggesting positive biological effects to prevent age-related diseases. Ginseng Berry Bioactive Content and CompositionThe bioactive components of ginseng are triterpene glycosides or saponins, which are commonly regarded as ginsenosides. AbstractA recent effort in the development of new medications and immune modulatory agents is to search for candidates among natural products because they have relatively low toxicities in clinica...

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“…4). Sirtuins may respond to small activator molecules [106,107], such as plant polyphenols, which confer their activating potential through FOXO3 binding to the Sirt1 mRNA. Sirt1 transcription is activated in mature osteoblasts (where miR-16 levels are diminished), compared to other cell types.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Regulatory Loops Consisting of Transcription Factors and microRNA Species Determine the Mineralizing Characteristics of Cell Phenotypes — Implications for Bone Engineering and Prevention of Soft Tissue Mineralization

Gordeladze¹,

Stakkestad²,

Haugen³

et al. 2014

Cells and Biomaterials in Regenerative Medicine

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Identification of a small molecule activator of SIRT1 gene expression

Cited by 25 publications

References 12 publications

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient

Regulatory Loops Consisting of Transcription Factors and microRNA Species Determine the Mineralizing Characteristics of Cell Phenotypes — Implications for Bone Engineering and Prevention of Soft Tissue Mineralization

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