Identification of a pharyngeal mucosal lymphoid organ in zebrafish and other teleosts: Tonsils in fish?

Resseguier, Julien; Nguyen-Chi, Mai; Wohlmann, Jens; Rigaudeau, Dimitri; Salinas, Irene; Oehlers, Stefan H.; Wiegertjes, Geert F.; Johansen, Finn-Eirik; Qiao, Shuo-Wang; Koppang, Erling O.; Verrier, Bernard; Boudinot, Pierre; Griffiths, Gareth

doi:10.1126/sciadv.adj0101

Cited by 9 publications

(2 citation statements)

References 83 publications

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“…The same study found a proliferation of B cells in the O-NALT after nasal vaccination, while other areas of the nasal cavity without known organized lymphoid structures did not demonstrate the same type of response [59]. Finally, this year, a pre-print manuscript was made available, describing an organized lymphoid structure named the Nemausen Lymphoid Organ (NEMO), found in the branchial cavity of teleost fish; this may be part of a larger immune complex including the ILT and ALT [60]. The recent increase in the identification of organized lymphoid structures over the last five years demonstrates how little is known about some areas of the teleost immune system.…”

Section: Organized Mucosal Lymphoid Tissuesmentioning

confidence: 99%

An Introduction to Relevant Immunology Principles with Respect to Oral Vaccines in Aquaculture

Jones,

Cain

2023

Microorganisms

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Vaccines continue to play an enormous role in the progression of aquaculture industries worldwide. Though preventable diseases cause massive economic losses, injection-based vaccine delivery is cost-prohibitive or otherwise impractical for many producers. Most oral vaccines, which are much cheaper to administer, do not provide adequate protection relative to traditional injection or even immersion formulas. Research has focused on determining why there appears to be a lack of protection afforded by oral vaccines. Here, we review the basic immunological principles associated with oral vaccination before discussing the recent progress and current status of oral vaccine research. This knowledge is critical for the development and advancement of efficacious oral vaccines for the aquaculture industry.

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Section: Organized Mucosal Lymphoid Tissuesmentioning

confidence: 99%

An Introduction to Relevant Immunology Principles with Respect to Oral Vaccines in Aquaculture

Jones,

Cain

2023

Microorganisms

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“…It is recommended that a new standard for assessing the severity of NF should be evaluated. [19][20][21][22][23][24][25] This study examines the correlation between sequential serum neutrophil levels and the overall improvement status or reduction rate of intravenous antibiotic administration. This study seeks to identify a cost-effective and easily accessible biomarker that can accurately predict the need for hospitalisation in patients with acute tonsillitis who are receiving intravenous broad-spectrum antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Serial neutrophils count as a stratifying tool for early follicular tonsilitis remission

Hayfa Suleiman Mefleh Obeidat,

Wajdi Nidal Jeries Smirat,

Mousa Mohammad Ali Almashagbah

et al. 2024

World J. Bio. Pharm. Health Sci.

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Background/Aim: This study examines the correlation between sequential serum neutrophil levels and the overall improvement status or reduction rate of intravenous antibiotic administration. This study seeks to identify a cost-effective and easily accessible biomarker that can accurately predict the need for hospitalisation in patients with acute tonsillitis who are receiving intravenous broad-spectrum antibiotics. The goal is to determine the patients' suitability for early discontinuation of intravenous antibiotics and discharge. Methods: This study was conducted at the King Hussein Medical Centre in Jordan, focusing on patients with severe acute tonsillitis who did not respond to oral antibiotics. Data was collected from the electronic medical record system (Hakeem) from January 2018 to May 2021. The study classified serial serum neutrophil measurements during the first week of hospital admission into four categories. The levels were compared between the non-penicillin Cohort (Group I) and penicillin Cohort (Group II) using an Independent-T Test. The outcomes of interest included a drop in neutrophil counts exceeding 50%, a decrease in the use of intravenous antibiotics in favor of oral antibiotics, and early eligibility for discharge. The study also examined serial neutrophil counts over the tested days and compared to the outcomes of positive and negative states using receiver operating curve analyses. The optimal cutoff operating point for each ROC curve was determined by selecting the highest Youden's index of each prognosticator day level. The analysis of all results was conducted using SPSS version 20 with a significance level set at p-value <0.05. Results: This study analyzed 1638 adult and elderly patients admitted to KHMC, RMS, Amman, Jordan between January 2018 and May 2021. The average age was 51.88±16.22 years, with patients dependent on intravenous penicillin being slightly older. The distribution of males and females was significant, with males making up 2.55 times the number of females. The odds ratio for positive outcomes was 4.12, with a high rate of poor outcomes in 1318 out of all eligible patients. A total of 994 (60.7%) medical patients were treated with intravenous administration, while 644 (39.3%) surgical patients were scheduled for a tonsillectomy procedure. The risk estimate for patients admitted from medical wards compared to surgical wards was an odds ratio of 0.562. The study also provided sensitivity analysis for the four tested serial neutrophil prognosticators at different day levels. Conclusion: The study supports the use of Somatic Nucleated Cell (SNC) as a reliable measure for evaluating EFR in cases of catarrhal acute tonsillitis. The maximum SNC count in Group one was 11,269 cells per cubic millimeter. Acute streptococcal infection often exhibits an ESR higher than 40, but this may be concealed by other complications. The SNC test has advantages like simplicity, quickness, and cost-effectiveness, but lacks specificity. Monitoring SNC and EFR fluctuations can initiate treatment cessation, preventing relapse and severe complications during recovery.

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Unravelling spermatogenesis in spotted wolffish: Insights from the ultrastructure of juvenile male testes to the cryopreservation of broodstock sperm

Superio,

Resseguier,

Nobrega

et al. 2024

Aquaculture

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Identification of a pharyngeal mucosal lymphoid organ in zebrafish and other teleosts: Tonsils in fish?

Cited by 9 publications

References 83 publications

An Introduction to Relevant Immunology Principles with Respect to Oral Vaccines in Aquaculture

An Introduction to Relevant Immunology Principles with Respect to Oral Vaccines in Aquaculture

Serial neutrophils count as a stratifying tool for early follicular tonsilitis remission

Unravelling spermatogenesis in spotted wolffish: Insights from the ultrastructure of juvenile male testes to the cryopreservation of broodstock sperm

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