2010
DOI: 10.1371/journal.pone.0011634
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Abstract: Staphylococcus aureus is a prominent human pathogen and leading cause of bacterial infection in hospitals and the community. Community-associated methicillin-resistant S. aureus (CA-MRSA) strains such as USA300 are highly virulent and, unlike hospital strains, often cause disease in otherwise healthy individuals. The enhanced virulence of CA-MRSA is based in part on increased ability to produce high levels of secreted molecules that facilitate evasion of the innate immune response. Although progress has been m… Show more

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Cited by 186 publications
(218 citation statements)
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“…Despite the lack of overlap in cellular targets identified thus far, the staphylococcal leukotoxins have been shown to exhibit synergistic effects (26). The identification of CD11b as a cellular target for LukAB provides an explanation for the previously reported synergism between LukAB and PVL toward human PMNs (10,11), as sublytic concentrations of PVL increase CD11b surface levels on these cells (27). From an evolutionary standpoint, the use of multiple, nonoverlapping cellular targets provides an explanation for why S. aureus has such a large arsenal of cytotoxins and is such a welladapted pathogen when it comes to evading host PMNs.…”
Section: Discussionmentioning
confidence: 96%
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“…Despite the lack of overlap in cellular targets identified thus far, the staphylococcal leukotoxins have been shown to exhibit synergistic effects (26). The identification of CD11b as a cellular target for LukAB provides an explanation for the previously reported synergism between LukAB and PVL toward human PMNs (10,11), as sublytic concentrations of PVL increase CD11b surface levels on these cells (27). From an evolutionary standpoint, the use of multiple, nonoverlapping cellular targets provides an explanation for why S. aureus has such a large arsenal of cytotoxins and is such a welladapted pathogen when it comes to evading host PMNs.…”
Section: Discussionmentioning
confidence: 96%
“…A single S. aureus strain can produce up to five different leukotoxins including two versions of γ-hemolysin (HlgAB and HlgCB), leukocidin E/D (LukED), Panton-Valentine leukocidin (PVL), and leukocidin A/B (LukAB, also known as LukGH) (4)(5)(6). The sequence similarity among these leukocidins ranges from 60% to 80% with the exception of LukAB, which is only 30-40% similar to the others (9,10). LukAB is the most recently identified member of the bicomponent leukocidin family (9,10).…”
mentioning
confidence: 99%
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“…SaeRS regulates transcription of multiple toxins, including γ-toxin (hlgA, hlgB, hlgC), LukSF-PVL, and LukAB/LukGH, which have been shown to contribute to PMN lysis (26)(27)(28)(29)(30)(31). Additionally, transcription of the saePQRS operon and SaeR target genes are activated in response to PMN phagocytosis and PMN components (32)(33)(34).…”
Section: Mutagenesis Of the Predicted Extracellular Loop Of Saes Idenmentioning
confidence: 99%