Identification of a new co-crystal of salicylic acid and benzamide of pharmaceutical relevance

Abstract

Raman spectroscopy, X-ray powder diffraction/X-ray crystallography and differential scanning calorimetry have been used to study the phenomenon of co-crystal formation in stoichiometric mixtures of salicylic acid with benzamide. Raman spectroscopy was particularly useful for the characterization of the products and was used to determine the nature of the interactions in the co-crystals. It was observed that little change in the vibrational modes associated with the phenyl groups of the respective reactants took place upon co-crystal formation, but changes in intensities of the vibrational modes associated with the amide and the carboxylic acid groups were observed upon co-crystal formation. Several new vibrational bands were identified in the co-crystal which were not manifested in the physical mixture of both components and could be used as diagnostic features of co-crystal formation.

Clozapine-carboxylic acid plasticized co-amorphous dispersions: Preparation, characterization and solution stability evaluation

“…Stable coamorphous systems have been prepared from low solubility drugs and small molecular mass amino acids (14) or neutral molecules capable of forming strong H-bonding such as saccharin (15) or nicotinamide (16). Although numerous successful plasticized formulations have been prepared using carboxylic acids (17)(18)(19)(20), plasticized co-amorphous dispersions prepared from crystalline drugs with polycarboxylic acids are rare. Moreover, no studies have addressed the use of carboxylic acid plasticizers (CAPs) in amorphization of solid crystalline drugs by employing solvent evaporation under vacuum as the method of preparation.…”

Development of Cosmetic Cream Containing a Pharmaceutical Cocrystal of Salicylic and Phenylalanine

“…Pharmaceutical cocrystallization is crystalline molecular complexes containing therapeutic molecules for the development of the active pharmaceutical ingredient (API) drugs [10,11]. Cocrystals are generally formed through noncovalent interaction bonds (primarily hydrogen bonding), π-π stacking, van der Waals interactions and other weak interactions [10][11][12].…”

An insight into the synthesis, crystal structure, geometrical modelling of crystal morphology, Hirshfeld surface analysis and characterization ofN-(4-methylbenzyl)benzamide single crystals

“…However, some other benzamide compounds act as potent Kv1.3 inhibitors and Kv1.3 ion channel blockers (Haffner, Thomson, Guo, Petrov et al, 2010;Haffner, Thomson, Guo, Schaller et al, 2010). Recently, Elbagerma et al (2010) investigated the formation of cocrystals from equimolar quantities of salicylic acid and benzamide for the enhancement of the physiochemical properties of the active pharmaceutical ingredient without changing the pharmaceutical activity.…”