2007
DOI: 10.1007/s00436-007-0596-6
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Abstract: Strongyloidiasis caused by the intestinal nematode Strongyloides stercoralis typically occurs in the asymptomatic form. The definitive diagnosis is usually done by detection of larvae on fecal samples. However, as the parasite load is often low in most cases, microscopy is not usually sensitive and specific, and diagnosis becomes extremely difficult. Thus, development of reliable serological methods is imperative. In the present study, a diversity of epitopes from S. stercoralis larva were characterized by ana… Show more

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Cited by 28 publications
(25 citation statements)
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References 38 publications
(42 reference statements)
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“…In order to overcome this drawback, Sato et al developed a gelatin particle agglutination (GPAT) test [86] and reported a sensitivity of 81% and a specificity of 74% [88]. Immunoblot analysis has been evaluated against immunodominant antigen of S.stercoralis and S.ratti , showing sensitivities between 65–100 [89], particularly higher when assessing IgG reactivity to a 41-KD [90] or 26 KDa larval component [91]. Several Enzyme-linked Immunosorbent Assays (ELISAs) have been developed for the diagnosis of strongyloidiasis.…”
Section: Resultsmentioning
confidence: 99%
“…In order to overcome this drawback, Sato et al developed a gelatin particle agglutination (GPAT) test [86] and reported a sensitivity of 81% and a specificity of 74% [88]. Immunoblot analysis has been evaluated against immunodominant antigen of S.stercoralis and S.ratti , showing sensitivities between 65–100 [89], particularly higher when assessing IgG reactivity to a 41-KD [90] or 26 KDa larval component [91]. Several Enzyme-linked Immunosorbent Assays (ELISAs) have been developed for the diagnosis of strongyloidiasis.…”
Section: Resultsmentioning
confidence: 99%
“…The major immunodominant antigens, which were composed of 29, 30, 31, 33, 33.5, 36, 44, and 56 kDa, were reacted with the IgG1, IgG4, and IgE antibodies from human strongyloidiasis sera (Atkins et al 1999). Conway et al (1993) reported that the immunodominant bands at the approximate molecular mass of 28, 31, and 41 kDa were reactive with human strongyloidiasis sera, while Sudre et al (2007) reported that the prominent 21, 26, and 33 kDa protein bands were reactive against human strongyloidiasis serum samples with a high level of frequency.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have presented various antigenic polypeptide bands from S. stercoralis L3 extract that react with human strongyloidiasis sera (Sato et al 1990;Conway et al 1993;Atkins et al 1999;Sudre et al 2007). The polypeptide bands at the approximate molecular mass of 26, 41, 66, and 97 kDa from S. stercoralis larvae were frequently recognized by the strongyloidiasis patients' sera (Sato et al 1990).…”
Section: Discussionmentioning
confidence: 99%
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“…According to western blots, the sera from infected patients can recognize different molecular antigenic patterns. For instance, Sato et al [111] revealed four antigens with molecular weights of 97, 66, 41, and 26 kDa; Ravi et al [112] described a 38 kDa molecule and Sudré et al [113] identified 26 and 33 kDa immunodominant molecules. However, no consensus or agreement in the literature has been reached regarding immunodominant S. stercoralis molecular patterns that can be used as standardized references for the diagnosis of strongyloidiasis.…”
Section: S Stercoralis Diagnosis and Treatmentmentioning
confidence: 99%