Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells

Wang, Juan; Wu, Jianpeng; Li, Xumei; Liu, Haowei; Qin, Jianli; Bai, Zhun; Chi, Bixia; Xu, Chen

doi:10.1016/j.jprot.2018.04.025

Cited by 37 publications

(32 citation statements)

References 61 publications

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“…C. kwangsiensis and C. phaeocaulis are advantageous for their antiproliferative activities against various cancer types [22][23][24][25][26][27]. Dried roots of C. zedoary enriched with curcumol are documented for their effective anticancer and antiinflammatory properties [28][29][30][31]. Rhizome of various Curcuma species, a rich source of curcumol, serves as antimicrobial, antifibrotic, and anticancer agent [32][33][34].…”

Section: Curcumol and Its Natural Sourcesmentioning

confidence: 99%

“…The summary of plants containing curcumol and biological activities are enlisted in Table 1. Figure 1 provides natural sources of curcumol including Astragali radix [36], C. aeruginosae [20], C. aromatica [21], C. kwangsiensis [22], C. longa [37], C. phaeocaulis [24], C. wenyujin [38], C. zedoary [28], Fructus gardenia [35], and C. trichosantha G. [39].…”

Section: Curcumol and Its Natural Sourcesmentioning

confidence: 99%

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Curcumol: From Plant Roots to Cancer Roots

et al. 2019

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Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent reservoir for the discovery of drugs since millennium. These naturally occurring, biologically active and therapeutically effective chemical entities have emerged as novel paradigm for the prevention of various diseases. This review aims to give an update on the sources as well as pharmacological profile of curcumol, a pharmacologically active sesquiterpenoid, which is an imperative bioactive constituent of several plants mainly from genus Curcuma. Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers. The reported data reveals multitarget activity of curcumol in cancer treatment suggesting its importance as anticancer drug in future. It is speculated that curcumol may provide an excellent opportunity for the cure of cancer but further investigations on mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural cancer killer in anticancer therapies.

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Section: Curcumol and Its Natural Sourcesmentioning

confidence: 99%

Section: Curcumol and Its Natural Sourcesmentioning

confidence: 99%

Curcumol: From Plant Roots to Cancer Roots

et al. 2019

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“…As the role of NCL in tumorigenesis of certain cancers is crucial, it could be a target protein for anticancer agents. A natural product, curcumol, exerts biological anticancer effects on nasopharyngeal carcinoma cells by NCL inhibition and it operates with minimal adverse effects (Wang et al 2018). …”

Section: A Nucleolus As a Support Of Cancer Cellsmentioning

confidence: 99%

The nucleolus, an ally, and an enemy of cancer cells

Stępiński

2018

Histochem Cell Biol

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The rates of ribosome production by a nucleolus and of protein biosynthesis by ribosomes are tightly correlated with the rate of cell growth and proliferation. All these processes must be matched and appropriately regulated to provide optimal cell functioning. Deregulation of certain factors, including oncogenes, controlling these processes, especially ribosome biosynthesis, can lead to cell transformation. Cancer cells are characterized by intense ribosome biosynthesis which is advantageous for their growth and proliferation. On the other hand, this feature can be engaged as an anticancer strategy. Numerous nucleolar factors such as nucleolar and ribosomal proteins as well as different RNAs, in addition to their role in ribosome biosynthesis, have other functions, including those associated with cancer biology. Some of them can contribute to cell transformation and cancer development. Others, under stress evoked by different factors which often hamper function of nucleoli and thus induce nucleolar/ribosomal stress, can participate in combating cancer cells. In this sense, intentional application of therapeutic agents affecting ribosome biosynthesis can cause either release of these molecules from nucleoli or their de novo biosynthesis to mediate the activation of pathways leading to elimination of harmful cells. This review underlines the role of a nucleolus not only as a ribosome constituting apparatus but also as a hub of both positive and negative control of cancer development. The article is mainly based on original papers concerning mechanisms in which the nucleolus is implicated directly or indirectly in processes associated with neoplasia.

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“…It has been reported that chemical biological methods can reveal the antitumor effect of various natural products. For instance, Wang et al identified nucleolin as curcumol's novel molecular target in nasopharyngeal carcinoma [28]. Liu et al demonstrated that adenanthin could induce the differentiation of acute promyelocytic leukemia (APL)-like cells, suppress tumor growth in vivo, and prolong the survival rate of mouse APL models by targeting peroxiredoxins I and II to induce cell differentiation [29].…”

Section: Introductionmentioning

confidence: 99%

Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine

Zhang

Gao

Cheng

et al. 2020

Cancers

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At present, melanoma is a common malignant tumor with the highest mortality rate of all types of skin cancer. Although the first option for treating melanoma is with chemicals, the effects are unsatisfactory and include poor medication response and high resistance. Therefore, developing new medicines or a novel combination approach would be a significant breakthrough. Here, we present cinnamaldehyde (CA) as a potential candidate, which exerted an antitumor effect in melanoma cell lines. Chemical biology methods of target fishing, molecular imaging, and live cell tracing by an alkynyl–CA probe revealed that the α-enolase (ENO1) protein was the target of CA. The covalent binding of CA with ENO1 changed the stability of the ENO1 protein and affected the glycolytic activity. Furthermore, our results demonstrated that dacarbazine (DTIC) showed a high promoting effect with CA for antimelanoma both in vivo and in vitro. The combination improved the DTIC cell cycle arrest in the S phase and markedly impacted melanoma growth. As a covalent inhibitor of ENO1, CA combined with DTIC may be beneficial in patients with drug resistance in antimelanoma therapy.

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Identification and validation nucleolin as a target of curcumol in nasopharyngeal carcinoma cells

Cited by 37 publications

References 61 publications

Curcumol: From Plant Roots to Cancer Roots

Curcumol: From Plant Roots to Cancer Roots

The nucleolus, an ally, and an enemy of cancer cells

Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine

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