Identification and cloning of the second type transglutaminase from Litopenaeus vannamei, and its transcription following pathogen infection and in relation to the haemolymph coagulation

Yeh, Maw-Sheng; Tsai, Wan-Lin; Cheng, Winton

doi:10.1016/j.fsi.2013.09.002

Cited by 21 publications

(4 citation statements)

References 41 publications

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“…Primary sequence comparison reveals significant homology among TGase from crustaceans and to a lesser extent with TGase from other arthropods and vertebrates [33,34,88,89]. Amino acid residues in the catalytic regions are fully conserved and the residues comprising the calcium-binding site share significant homology.…”

Section: Transglutaminasesmentioning

confidence: 99%

“…In shrimps, two types of TGase were identified, which accordingly to phylogenetic analysis can be separated into two groups, Type I and Type II [35,36,89]. The expression of TGases can be modulated by microbial stimuli and its expression level is related with success against microbial infections [22].…”

Section: Transglutaminasesmentioning

confidence: 99%

“…The expression of TGases can be modulated by microbial stimuli and its expression level is related with success against microbial infections [22]. The Type II TGase described in L. vannamei [89] and P. monodon [36] seems to be the one most engaged in hemolymph coagulation.…”

Section: Transglutaminasesmentioning

confidence: 99%

“…Amino acid residues in the catalytic regions are fully conserved and the residues comprising the calcium-binding site share significant homology. In addition, a variable number of RGD (Arg-Gly-Asp) motifs are present in most crustacean TGase [34,65,88,89], and their positions are markedly conserved across invertebrates [87].…”

Section: Transglutaminasesmentioning

confidence: 99%

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The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models

Perdomo-Morales¹,

Montero-Alejo²,

Perera

2019

Fish & Shellfish Immunology

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Hemolymph coagulation is among the major arms of the humoral immune response in crustaceans. According to the current model, hemolymph clotting in decapod crustacean relies mostly on the polymerization of the plasmatic clotting protein (CP) which is directly promoted by calcium-depended transglutaminase (TGase) released from hemocytes upon microbial stimulus or injury. However, the type of hemocytes containing TGase, and hence how the TGase is released, might vary among species. Thus, we discourse here about possible mechanisms for clotting initiation. On the other hand, the initiation of coagulation reaction in the absence of microbial elicitors is poorly understood and seems to involve hemocytes lability, yet the mechanism remains unknown. A cellular clottable protein called coagulogen, different to the plasma CP, occurs in several species and could be related with the immune response, but the biological relevance of this protein is unknown. It is also demonstrated that the clotting response is actively involved in defense against pathogens. In addition, both TGase and the CP show pleiotropic functions, and although both proteins are relatively conserved, some of their physic-chemical properties vary significantly. The occurrence of differences in the clotting system in crustaceans is conceivable given the high number of species and their diverse ecology. Results from still non-studied decapods may provide explanation for some of the issues presented here from an evolutionary perspective.

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Section: Transglutaminasesmentioning

confidence: 99%