2011
DOI: 10.5155/eurjchem.2.2.152-157.170
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Abstract: KEYWORDSThe degradation of eprosartan was evaluated under ICH/WHO prescribed stress conditions. The drug degraded to only one product under photo alkali condition, whereas it was stable to conditions of hydrolysis, oxidation and thermal stress. The drug and its co-eluting product were well separated on RP-HPLC in a gradient mode. Subsequently, LC-MS/TOF and on-line H/D exchange studies were performed on both of them. The two showed same molecular mass, similar fragment ions and even the same number of labile h… Show more

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Cited by 9 publications
(9 citation statements)
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References 12 publications
(9 reference statements)
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“…Eprosartan belongs to familly of betablockers and is frequently detected in wastewater at moderately to high concentrations. Analysis of TOF‐MS/MS spectra reported by Shah et al . and MS/MS spectra reported by Grabic et al .…”
Section: Resultsmentioning
confidence: 99%
“…In specific case of isomeric changes, the fragmentation pathway of the drug and the product should be similar, but an interesting aspect to look for in this case is the difference in relative abundance of lines in the mass spectra of the drug and IMPs/DPs. A case is cited in the literature where a photolytic isomeric DP of eprosartan was found to yield relatively different fragment ion intensities in MS/TOF spectra than the drug [153]. This could be explained through hindered protonation of thiophene ring due to its proximity with vinyl hydrogen as a result of its altered geometry in the structure of DP (Fig.…”
Section: Gaining Additional Information From Acquired Datamentioning
confidence: 93%
“…More specific applications of 1D and 2D LC-NMR in understanding inherent degradation behavior of APIs and the formation of DPs in formulations were critically described by Pan et al [103]. There are several other reports on the use of LC-NMR for structural characterization of IMPs and degradation/interaction products [39,122,153,168,[225][226][227][228][229][230][231][232][233][234][235][236][237][238][239][240][241][242]. A compilation is separately given in Table S4, which includes details of drugs/compounds investigated, IMPs/DPs characterized, their amount in the sample, instrument configuration, operation mode, etc.…”
Section: Lc-nmrmentioning
confidence: 96%
See 1 more Smart Citation
“…Residual solvents analysis in EPR was also performed by static headspace GC method . Shah et al have characterized a photolytic degradant of EPR using LC–MS/MS and LC–NMR , whereas Sun et al have characterized a novel impurity, EPR dimer connected via methylene using LC–MS/MS and NMR . Recently, an HPLC method has been developed for the separation of EPR analogues and their characterization by LC–MS/MS and NMR techniques .…”
Section: Introductionmentioning
confidence: 99%