Identification and analysis of differential miRNA–mRNA interactions in coronary heart disease: an experimental screening approach
Jie Wang,
Lanchun Liu,
Chao Liu
et al.
Abstract:ObjectiveThis aim of this study is to screen the differential molecules of kidney deficiency and blood stasis (KDBS) syndrome in coronary heart disease by high-throughput sequencing. In addition, the study aims to verify the alterations in the expression levels of miR-4685-3p and its regulated downstream, namely, C1QC, C4, and C5, using quantitative polymerase chain reaction (qPCR) and enzyme-linked immunosorbent assay (ELISA), and to determine whether the complement and coagulation cascade pathway is the spec… Show more
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