Ideal homes? Housing effects on rodent brain and behaviour

Würbel, Hanno

doi:10.1016/s0166-2236(00)01718-5

Cited by 400 publications

(242 citation statements)

References 47 publications

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“…Standardization of bedding materials may help reduce inter-experimental variability within and across laboratories by reducing behaviorally anxious phenotypes. Importantly, bedding standardization can also enhance animal welfare by diminishing adult anxiety-like behavior in animals, which is assumed to be deleterious and maladaptive in the laboratory setting [13,48]. Equally, the conditions in which environments are involved in programming animal behavior may serve as important criteria to rene future research [13].…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, bedding standardization can also enhance animal welfare by diminishing adult anxiety-like behavior in animals, which is assumed to be deleterious and maladaptive in the laboratory setting [13,48]. Equally, the conditions in which environments are involved in programming animal behavior may serve as important criteria to rene future research [13]. For instance, when strong anxious phenotypes are required for research purposes, bedding type may also be considered as one avenue to potentiate behavioral effects.…”

Section: Discussionmentioning

confidence: 99%

“…In the laboratory, different animal housing conditions at various points in the lifespan of the organism (such as providing more complex/enriched cages, or conversely, deprivation) can also inuence stress-axis function and behavior. Many studies, including a seminal paper by Crabbe et al illustrate how minor changes in standard laboratory environments can abolish or reverse genetic effects of behavior in laboratory mice [12,13]. Providing enriched housing conditions to mice typically housed under standard laboratory housing conditions is sufcient enough to attenuate non-spatial memory impairments in NMDA knockout mice, possibly by increasing synaptogenesis [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Many studies, including a seminal paper by Crabbe et al illustrate how minor changes in standard laboratory environments can abolish or reverse genetic effects of behavior in laboratory mice [12,13]. Providing enriched housing conditions to mice typically housed under standard laboratory housing conditions is sufcient enough to attenuate non-spatial memory impairments in NMDA knockout mice, possibly by increasing synaptogenesis [13,14]. Little is known about which specic features of laboratory housing contribute to changes in rodent phenotypes.…”

Section: Introductionmentioning

confidence: 99%

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Influence of housing variables on the development of stress-sensitive behaviors in the rat

Sakhai

Preslik

Francis

2013

Physiology & Behavior

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• Laboratory bedding material inuences developmental programming of rats.• Bedding material during early life can alter stress sensitive measures in adulthood.• Corncob bedding during sensitive periods decreases adult measures of anxiety.• Bedding material during adulthood does not affect adult anxiety-like behavior. Diverse environments early in mammalian life can have profound inuences on the physiology and behavior of developing offspring. Environmental factors can inuence offspring development directly or through perturbations in parental care. In the current study, we wished to determine if the inuence of a single environmental variable, type of bedding material used in laboratory cages, is capable of altering physiological and behavioral outcomes in offspring. Female rats were housed in cages containing wood pulp or corncob bedding and allowed to mature. These rats, while housed on assigned bedding material, were bred and allowed to give birth. At weaning, male offspring were housed on one of the two bedding conditions and tested later in adulthood on stress-sensitive behavioral measures. Postmortem analysis of glucocorticoid receptor expression and CRH mRNA levels were also measured. Maternal care directed at the pups reared in the two different bedding conditions was also recorded. Rats reared from birth on corncob bedding exhibited decreased anxiety-like behavior, as adults, in both open eld and light-dark box tasks compared to wood pulp reared animals. Animals that received similar overall levels of maternal care, regardless of bedding condition, also differed in anxiety-like behaviors as adults, indicating that the bedding condition is capable of altering phenotype independent of maternal care. Despite observed behavioral differences in adult offspring reared in different bedding conditions, no changes in glucocorticoid receptor expression at the level of the hippocampus, frontal cortex, or corticotrophin releasing hormone (CRH) mRNA expression in the hypothalamus were observed between groups. These results highlight the importance of early life housing variables in programming stress-sensitive behaviors in adult offspring. a b s t r a c t a r t i c l e i n f oPublished by Elsevier Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of housing variables on the development of stress-sensitive behaviors in the rat

Sakhai

Preslik

Francis

2013

Physiology & Behavior

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“…Some of these researches uses animal in restrained position where animals do not have access to water or food during exposure. This restrained position is reported causing stress related changes in [17,20] and imposes constraints on behavior and brain development of the animals [21]. The study of long term effect in this condition is also not appropriate as no exposures per day and per week will be identical leading to serious comparative difficulties as reported in [16,22,23].…”

Section: Introductionmentioning

confidence: 99%

MICROWAVE EFFECT OF 0.9 GHz AND 1.8 GHz CW FREQUENCIES EXPOSED TO UNRESTRAINED SWISS ALBINO MICE

Usman

Ahmad

Kadir

et al. 2012

PIER B

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Abstract-Long term radio frequency electromagnetic field (RF EMF) exposures due to Global System for Mobile communication (GSM) frequencies were investigated in this study. 158 Swiss Albino mice in unrestrained conditions were used as surrogate and divided into four groups. The average peak field strength generated and measured inside the cages placed at a far field from the antennas is 0.6 × 10 −3 mW/cm 2 , and the specific absorption rate at 0.9 GHz and 1.8 GHz is 2.33 × 10 −3 W/kg and 1.97 × 10 −4 W/kg, respectively. Three samples of the mice chosen at random each from sham and exposed groups in week 4 and subsequently biweekly basis were taken for haematology and histopathology tests. The complete blood count result shows that haematological parameters of both the sham exposed and exposed mice were within the normal range of mice in the control group. A statistical analysis was conducted to determine whether differences observed between the experimental groups were significant. The histopathology examination on some internal organs shows that spleen and bone marrow of the mice were normal for all the three experimental groups, while a sign of tissue degeneration and inflammations were observed after 8 weeks of exposure on the brain,

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Minimizing Variation Due to Genotype and Environment

Argmann

Auwerx

2006

CP Molecular Biology

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Mouse models are increasingly popular tools to study and characterize the molecular and physiological bases for human diseases. Due to the readily available genetic tools to construct mouse models of complex diseases, the flow of efficient and vigilant mouse phenotyping has now become the bottleneck in mouse functional genomics. This unit addresses the importance of minimizing and defining confounding genetic and environmental sources of variability.

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Ideal homes? Housing effects on rodent brain and behaviour

Cited by 400 publications

References 47 publications

Influence of housing variables on the development of stress-sensitive behaviors in the rat

Influence of housing variables on the development of stress-sensitive behaviors in the rat

MICROWAVE EFFECT OF 0.9 GHz AND 1.8 GHz CW FREQUENCIES EXPOSED TO UNRESTRAINED SWISS ALBINO MICE

Minimizing Variation Due to Genotype and Environment

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