A 31 year old woman primigravida was admitted in spontaneous labour at 38 weeks of gestation, having had an otherwise uneventful pregnancy. She was 1.66m tall and weighed 89kg at the time of her booking. Examination showed her cervix to be 4 cm dilated with the station of the fetal head 1cm above the ischial spines and that the membranes were intact. The fetal heart rate was 110 beats per minute (bpm) and cardiotocography was started which showed early decelerations. Arti®cial rupture of the membranes was performed and clear amniotic¯uid was drained. Diamorphine (10mg intramuscularly) was given for pain relief. There was no change in cervical dilatation at the next examination, and an oxytocin infusion was ordered. Epidural analgesia was administered.The epidural catheter was inserted without dif®culty and following a test dose of 3ml 2% lignocaine, her systolic/diastolic blood pressure was 166/74mmHg, with pulse rate 81 bpm. There were no signs of incorrect placement of the epidural catheter. During this time the fetal heart rate decreased to 70 bpm; this bradycardia did not respond to changing the position of the woman and the administration of oxygen. The fetal bradycardia persisted for seven minutes when a decision to perform a caesarean section was made. In view of this prolonged fetal bradycardia and the fact that the ®rst`top up ' had not yet been given through the epidural catheter, it was felt there was insuf®-cient time to establish adequate epidural anaesthesia for the caesarean section. The woman was transferred to the operating theatre and preparations made to administer general anaesthesia. No further drugs were administered into the epidural catheter.Based on an estimated weight of .100kg, thiopentone (500mg) and suxamethonium (100mg) were administered intravenously and endotracheal intubation was performed successfully. Immediately after the intubation, her pulse, blood pressure, oxygen saturation and end-tidal CO 2 were normal; and bilateral air entry into the lungs was con®rmed by auscultation. The endotracheal tube was then secured and mechanical ventilation started. Soon thereafter ventilation became rapidly progressively dif®cult, and her oxygen saturation decreased to 80-90%. The endotracheal tube was found to be patent and in the correct position, and 100% oxygen was given. Despite this her oxygen saturation decreased to 60%, auscultation of the chest revealed respiratory and expiratory rhonchi, and a diagnosis of anaphylaxis was considered. Her pulse became weak, her heart rate was less than 40 beats per minute, her blood pressure was unrecordable, her oxygen saturation was less than 50% and her end-tidal CO 2 , 10mmHg. Other than the severe bronchospasm and cardiovascular collapse, there were no other signs of anaphylaxis such as urticaria and angioreuratic oedema.Adrenaline (1mg intravenously) was given, cardiopulmonary resuscitation was started and a caesarean section was performed to facilitate maternal resuscitation. Four and a half minutes had elapsed between the intravenous induct...