Icosahedral DNA Nanocapsules by Modular Assembly

Abstract

It's a trap! DNA polyhedra formed through molecular self-assembly may function as nanocapsules for the targeted delivery of encapsulated entities. This functional aspect was demonstrated for the most complex DNA-based platonic solid: During the stepwise amalgamation of discrete polyhedra to form icosahedra, gold nanoparticles (GNPs) were encapsulated from solution (see illustration and TEM image of icosahedral cages containing GNPs).

Self‐Assembly of Functionalizable Two‐Component 3D DNA Arrays through the Induced Formation of DNA Three‐Way‐Junction Branch Points by Supramolecular Cylinders

“…[4,5] Furthermore, it has been shown that DNA can be designed to organize into extended arrays, such as 2D [6] and 3D crystals. [7,8] Branching points have so far been incorporated in these materials by including DNA four-way ("Holliday") junctions or by covalent modification.…”

Functionalized DNA Nanostructures for Nanomedicine

“…For example, there have been various reports of the assembly of hollow DNA cages to encapsulate nanoparticles [65][66][67] and proteins, [68,69] other carriers that display cargo molecules on their surface, [70] and simple double-helical structures that intercalating drugs can be loaded into. [71,72] Meanwhile, because DNA objects can function as reconfigurable nanomachines, [14,68] it is expected that DNA nanostructures can be translated into controllable drug-release vehicles.…”

Supramolecular Wireframe DNA Polyhedra: Assembly and Applications

“…Differently, Krishnan et al reported a stochastic encapsulation of gold nanoparticles from solution in a DNA icosahedron formed in-situ, by complexing two half-icosahedra bearing complementary overhangs. [61] Each of the icosahedral halves was a self-assembled product of six 5-way junctions (two of which were unique).…”