Ichthyosis and Psoriasis in a Patient with Down Syndrome

Nomura, Kazuo

doi:10.1111/j.1346-8138.1999.tb02043.x

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Two case reports included patients with features of ichthyosis vulgaris; both cases were reported to clinically resemble ichthyosis vulgaris and were supported by histologic findings but were missing features of early onset in life and positive family history [ 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two observational studies reported the prevalence of ichthyosis vulgaris in patients with DS, with a mean prevalence of 4.7% (14/298) [2,12]. Two case reports included patients with features of ichthyosis vulgaris; both cases were reported to clinically resemble ichthyosis vulgaris and were supported by histologic findings but were missing features of early onset in life and positive family history [29,30].…”

Section: Ichthyosismentioning

confidence: 99%

“…Moreover, there were 14 case reports and 1 case series with 17 patients in total, where 3 (17.6%) of the patients had psoriatic arthritis (Multimedia Appendix 3) [29,[41][42][43][44][45][46][47][48][49][50][51][52][53][54]. Six studies reported failed or ineffective systemic treatment with immunosuppressants [41,45,46,51,52], including the study by Adamcyzk et al [41], who reported discontinuing cyclosporin A treatment due to elevated liver enzymes, and Alcaide et al [42], who reported contraindications for cyclosporin and methotrexate due to renal and liver problems, respectively.…”

Section: Psoriasismentioning

confidence: 99%

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Common Dermatologic Disorders in Down Syndrome: Systematic Review

Lam¹,

Lu²,

Elhadad³

et al. 2022

JMIR Dermatol

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Background Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatologic conditions, including hidradenitis suppurativa, have also been found to be associated with DS. Objective The objective of this study was to characterize the prevalence, presentation, and unique features of dermatologic disorders associated with DS. Methods Electronic searches of EMBASE (via Ovid), MEDLINE (via Ovid), and Web of Science databases were conducted on December 14, 2020. Observational studies including case reports of patients with DS presenting with concomitant primary dermatologic disorder were included. Results This systematic review captured 40 observational studies and 99 case reports, including 10 observational studies that examined the prevalence of common skin disorders in patients with DS. The most common dermatologic conditions reported includes atopic dermatitis (8 studies, n=180; 19.7% mean prevalence), hidradenitis suppurativa (15, n=478; 3.2%), ichthyosis (4, n=16; 4.7%), lichen nitidus (6, n=6; 1.1%), psoriasis (21, n=65; 4.8%), alopecia areata (27, n=253; 7.4%), vitiligo (8, n=40; 4.4%), onychomycosis (3, n=198; 24.7%), calcinosis cutis (14, n=15), connective tissue nevi (6, n=6), dermatofibroma (3, n=3), melanoma (3, n=3), syringomas (14, n=182; 21.2%), and elastosis perforans serpiginosa (19, n=24; 0.5%). Conclusions Our results indicate an increased prevalence of common cutaneous disorders in patients with DS, particularly infectious, inflammatory, autoimmune, and connective tissue conditions. Current guidelines for the screening, general management, and use of systemic immunomodulatory agents in this patient population are lacking. Patients with DS would benefit from screening for dermatologic disorders not otherwise regularly performed for earlier diagnosis and treatment. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42021226295; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=226295

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Section: Resultsmentioning

confidence: 99%

Section: Ichthyosismentioning

confidence: 99%

Section: Psoriasismentioning

confidence: 99%

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Common Dermatologic Disorders in Down Syndrome: Systematic Review

Lam¹,

Lu²,

Elhadad³

et al. 2022

JMIR Dermatol

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“…No such association has been reported in literature so far. A few other numerical abnormalities reported in literature are, a 16-year-old girl with x-linked ichthyosis and Turner's syndrome, a 24-year-old man with Down syndrome and prominent ichthyosiform skin and a Klinefelter Syndrome with ichthyosis vulgaris and pulmonary stenosis [9][10][11]. The case is reported for its rarity and for being the first of its kind to be reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Non-bullous Ichthyosiform Erythroderma with Mosaic Turner’s Syndrome - a Rare Association

Audhya¹,

Uma²,

Shobana³

et al. 2014

J Clin Exp Dermatol Res

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“…El prurito, cuando está presente, agrava la Ps a través del rascado alterando el sueño y la sociabilidad, esto se traduce en alteración de la calidad de vida. En pacientes con SD se reportaron casos aislados de Ps (Rotchford, Wash y Hyman, 1961;Schepis, Siragusa y Happlee, 2017;Marmon, De Souza y Strober, 2012;Sugiura y col., 2015;Iribas y col., 2018;Nomura, 1999) sin demostrar una prevalencia en esta población respecto a quienes no padecen de SD (Thomas y col., 1994). Polenghi y col., (1990), comunicaron una prevalencia del 8% entre 50 pacientes con SD.…”

Section: Introductionunclassified

Prevalencia de psoriasis en pacientes con Síndrome de Down

Salva,

Vassallo,

Quiñoñes

et al. 2023

sigme

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La psoriasis (Ps) es una de las dermatosis que pueden afectar a los pacientes con síndrome de Down (SD). Su presentación clínica es variada, se han reportado formas graves, en algunos casos asociadas a artritis (APs), siendo la dermatitis atópica (DA), la dermatitis seborreica (DS), la xerodermia y la queratodermia los hallazgos cutáneos más frecuentes en esta población. Nuestro objetivo fue determinar la prevalencia de Ps en el SD, a través de un trabajo observacional, descriptivo y transversal. Nuestros resultados mostraron una prevalencia del 8,33% en 60 pacientes con SD examinados, no siendo diferentes de los valores obtenido en la literatura.

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Ichthyosis and Psoriasis in a Patient with Down Syndrome

Cited by 5 publications

References 11 publications

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Common Dermatologic Disorders in Down Syndrome: Systematic Review

Non-bullous Ichthyosiform Erythroderma with Mosaic Turner’s Syndrome - a Rare Association

Prevalencia de psoriasis en pacientes con Síndrome de Down

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