Ichthyosiform sarcoidosis

Abstract

A 31-year-old black woman had acquired ichthyosis. Histologic examination of her skin revealed a sarcoidal reaction in the dermis. The diagnosis of sarcoidosis was supported by negative tuberculin (intermediate strength purified protein derivative) and Candida albicans extract intradermal skin tests; by a positive Kveim test; and by roentgenographic evidence of bilateral hilar adenopathy, paratracheal node enlargement, and diffuse pulmonary parenchymal changes. Sarcoidosis must be considered when acquired ichthyosis develops in a patient.

Interstitial Granulomatous Lesions as Part of the Spectrum of Presenting Cutaneous Signs in Pediatric Sarcoidosis

“…In IGD, the neutrophilic infiltrate is variable ( Table 2) (18)(19)(20)(21). A recent study of lesional skin biopsies from systemic sarcoidosis patients (3) supported previous reports which had suggested that the histologic spectrum of cutaneous sarcoidosis might be more diverse than generally thought (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). While classic noncaseating sarcoidal granulomas were identified in a great majority of skin specimens, the study also showed several other histologic patterns, including GA.…”

“…Variability in sarcoidosis is not limited to macroscopic skin findings. While naked sarcoidal granulomas are the classic histologic finding in sarcoidosis, many other histologic presentations of skin lesions in sarcoidosis patients have been described (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15).…”

“…Clinical and Histologic Characteristics of Juvenile Sarcoidosis, Granuloma Annulare, Palisaded Neutrophilic and Granulomatous Dermatitis, and Blau Syndrome(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(18)(19)(20)(21)33,34) …”

Ichthyosis and Psoriasis in a Patient with Down Syndrome

“…Immunological and autoimmune factors have been implicated in the etiology of acquired ichthyosis. These include sarcoidosis (6), atopic dermatitis, and systemic lupus erythematosus (7). Recently, many immunological abnormalities have been reported in Down syndrome.…”