Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants

The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study

“…Similar findings were reported using speckle-tracking echocardiography [11]. The initial decrease could result from an ischemic effect caused by indomethacin, reported to decreasing flow to organs like the intestines and kidneys [2,5]. Our study, in accordance with the previous reports [10,11], though at different time points and different medications, did not show an increase in coronary flows 4.1 ± 2.8 days post PDA treatment.…”

The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study

“…Similar findings were reported using speckle-tracking echocardiography [11]. The initial decrease could result from an ischemic effect caused by indomethacin, reported to decreasing flow to organs like the intestines and kidneys [2,5]. Our study, in accordance with the previous reports [10,11], though at different time points and different medications, did not show an increase in coronary flows 4.1 ± 2.8 days post PDA treatment.…”

Randomized Trial to Compare Renal Function and Ductal Response between Indomethacin and Ibuprofen Treatment in Extremely Low Birth Weight Infants

“…The effect of ibuprofen and indomethacin on renal function in our study was consistent with that of a recent Cochrane review [9]. However, in contrast to this Cochrane review finding that ibuprofen was as effective as indomethacin in closing PDA, we found that intravenous indomethacin therapy was associated with a higher chance of persistent ductal closure as compared to intravenous ibuprofen therapy.…”

Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies

“…On the other hand, our results are in partial agreement with a Cochrane review published in 2018 [7] concluding that ibuprofen is as effective as indomethacin in closing PDA while reducing the risk of NEC and transient renal insufficiency, and with another Cochrane review published in 2018 [104] concluding that paracetamol is as effective as ibuprofen in closing a PDA, with a possibly lower risk of gastrointestinal and renal AEs.…”

The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study

“…Similar findings were reported using speckle-tracking echocardiography [11]. The initial decrease could result from an ischemic effect caused by indomethacin, reported to decreasing flow to organs like the intestines and kidneys [2,5]. Our study, in accordance with the previous reports [10,11], though at different time points and different medications, did not show an increase in coronary flows 4.1 ± 2.8 days post PDA treatment.…”

Randomized Trial to Compare Renal Function and Ductal Response between Indomethacin and Ibuprofen Treatment in Extremely Low Birth Weight Infants

“…The effect of ibuprofen and indomethacin on renal function in our study was consistent with that of a recent Cochrane review [9]. However, in contrast to this Cochrane review finding that ibuprofen was as effective as indomethacin in closing PDA, we found that intravenous indomethacin therapy was associated with a higher chance of persistent ductal closure as compared to intravenous ibuprofen therapy.…”

Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies

“…On the other hand, our results are in partial agreement with a Cochrane review published in 2018 [7] concluding that ibuprofen is as effective as indomethacin in closing PDA while reducing the risk of NEC and transient renal insufficiency, and with another Cochrane review published in 2018 [104] concluding that paracetamol is as effective as ibuprofen in closing a PDA, with a possibly lower risk of gastrointestinal and renal AEs.…”

The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study

“…Similar findings were reported using speckle-tracking echocardiography [11]. The initial decrease could result from an ischemic effect caused by indomethacin, reported to decreasing flow to organs like the intestines and kidneys [2,5]. Our study, in accordance with the previous reports [10,11], though at different time points and different medications, did not show an increase in coronary flows 4.1 ± 2.8 days post PDA treatment.…”

Randomized Trial to Compare Renal Function and Ductal Response between Indomethacin and Ibuprofen Treatment in Extremely Low Birth Weight Infants

“…The effect of ibuprofen and indomethacin on renal function in our study was consistent with that of a recent Cochrane review [9]. However, in contrast to this Cochrane review finding that ibuprofen was as effective as indomethacin in closing PDA, we found that intravenous indomethacin therapy was associated with a higher chance of persistent ductal closure as compared to intravenous ibuprofen therapy.…”

Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies

“…On the other hand, our results are in partial agreement with a Cochrane review published in 2018 [7] concluding that ibuprofen is as effective as indomethacin in closing PDA while reducing the risk of NEC and transient renal insufficiency, and with another Cochrane review published in 2018 [104] concluding that paracetamol is as effective as ibuprofen in closing a PDA, with a possibly lower risk of gastrointestinal and renal AEs.…”