2018
DOI: 10.18632/aging.101448 View full text |Buy / Rent full text
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Abstract: Xeroderma pigmentosum group G (XPG), a key component in nucleotide excision repair pathway, functions to cut DNA lesions during DNA repair. Genetic variations that alter DNA repair gene expression or function may decrease DNA repair ability and impair genome integrity, thereby predisposing to cancer. The association between XPG rs17655 G>C polymorphism and cancer risk has been investigated extensively, but the results remain contradictory. To get a more accurate conclusion, we performed a comprehensive meta-an… Show more

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“…Articles selected [ 2 , 7 , 10 , 14 , 18 23 ] for qualitative assessment are presented in Table 1 . After 504 abstracts screening, 13 full-text articles were assessed for eligibility, and 3 of them were excluded: one article was focused only on the association of XP with gastric cancer, one did not fit the topic and represented a limit of the online database search, one article had a control study design, so was excluded having low evidence level.…”
Section: Resultsmentioning
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“…Articles selected [ 2 , 7 , 10 , 14 , 18 23 ] for qualitative assessment are presented in Table 1 . After 504 abstracts screening, 13 full-text articles were assessed for eligibility, and 3 of them were excluded: one article was focused only on the association of XP with gastric cancer, one did not fit the topic and represented a limit of the online database search, one article had a control study design, so was excluded having low evidence level.…”
Section: Resultsmentioning
“…Several types of malignancy have been correlated with XP syndrome: gastric, breast, bladder, colorectal, lung, endometrial, brain, head and neck, prostate and melanoma, and nonmelanoma skin cancers (NMSC) [ 10 ].…”
Section: Introductionmentioning
“…The next strongest predictor in the top performing model is located within ERCC5/XPG (mean Gini = 1.15), located on chromosome 13q22-33 which causes a G > C (His1104Asp) change in the last (15th) exon of the gene (rs17655) (Zhao et al, 2018). ERCC5 is an excision repair gene that is responsible for forming the 3' incision during nucleotide excision repair (NER) and is known to be extremely polymorphic (Zhao et al, 2018). The variant is located within the C-terminal of the gene and inhibits interactions of ERCC5 with other DNA repair proteins (Xu et al, 2016).…”
Section: Discussionmentioning
“…Damaging variants in this gene can lead to deficiencies in the NER pathway, causing xeroderma pigmentosum (XP) and Cockayne syndrome (CS), both of which result in symptoms shared with phenotypic aging ( O'Donovan et al, 1994;Barnhoorn et al, 20 14). Additionally, this specific variant, rs17655, is well-studied for its association with cancer risk, especially in gastric and colon cancer (Zhao et al, 2018). The well-established relationship between accelerated aging and deficient DNA damage repair (Gensler and Bernstein, 1981), in addition to the high importance this variant has in our top performing model, leads to the hypothesis that ERCC5 is important for attenuating the aging process.…”
Section: Discussionmentioning
“…Moreover, the absorption spectrum can be expanded to the visible light region by optimizing the metal species and ligand groups . The smooth charge mobility between the metal species and the ligand groups would significantly accerlate the multielectron reduction of CO 2 . Nevertheless, the inferior photostability of metal complexes becomes one of the serious issues in the PC process .…”
Section: Introductionmentioning