<i>XPG</i>
            Polymorphisms And Their Association With Lung Cancer Susceptibility, Overall Survival And Response In North Indian Patients Treated With Platinum-Based Doublet Chemotherapy

Lawania, Shweta; Singh, Navneet; Behera, Digambar; Sharma, Siddharth

doi:10.2217/fon-2018-0408

Cited by 5 publications

(1 citation statement)

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“…Some studies have demonstrated that the single nucleotide polymorphisms (SNPs) of XPG may affect the development of cancer, such as lung cancer[12,13], colorectal cancer[14,15], breast cancer[16], neuroblastoma[17], Hodgkin’s lymphoma[18], and oral squamous cell carcinoma[19]. However, only a few studies have explored the associations between XPG gene SNPs and GC, and those studies show inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Wang¹,

Terry²,

Yang³

et al. 2019

WJG

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BACKGROUNDThe xeroderma pigmentosum group G (XPG) gene at chromosome 13q33 consists of 15 exons, which may be related to the occurrence and development of gastric cancer (GC).AIMTo examine the association of several common single nucleotide polymorphisms (SNPs) of the XPG gene with GC risk and survival.METHODSFive SNPs of XPG (rs2094258, rs751402, rs873601, rs2296147, and rs1047768) were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China. GC patients were followed for survival status and, if deceased, cause of death. Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis, respectively. For rs2094258, heterozygous model (CT vs CC), homozygous model (TT vs CC), recessive model (TT vs CT + CC), and dominant model (TT + CT vs CC) were analyzed.RESULTSNone of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (P = 0.050). GC patients with the rs2094258 CT + CC genotype showed worse survival than those with the TT genotype (log-rank test, P = 0.028), and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT + CT genotype (log-rank test, P = 0.039). The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, P = 0.037] were associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation (HR = 4.51, 95%CI: 1.99-8.23, P < 0.001), lymphovascular invasion (HR = 1.97, 95%CI: 1.44-3.01, P < 0.001), and use of chemotherapy (HR = 0.81, 95%CI: 0.63-0.98, P = 0.041).CONCLUSIONThe XPG rs2094258 polymorphism may be associated with overall survival in GC patients.

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