“…Somatic sexual fates in C. elegans are specified by the global sex‐determination pathway, the terminal effector of which is the transcription factor TRA‐1 (sexual transformer) that exists in two major isoforms, A and B (Zarkower & Hodgkin, 1992). TRA‐1 is orthologous to mammalian GLI (glioma‐associated) and Drosophila Ci (Cubitus interruptus) proteins and determines hermaphrodite features by repressing the expression of male‐specific genes (Berkseth, Ikegami, Arur, Lieb & Zarkower, 2013; Chen & Ellis, 2000; Conradt & Horvitz, 1999; Hargitai et al., 2009; Mason, Rabinowitz & Portman, 2008; Schwartz & Horvitz, 2007; Szabó et al., 2009; Yi, Ross & Zarkower, 2000). In males, TRA‐1 appears to play only a minor role (Schvarzstein & Spence, 2006).…”