The Histopathology of Enteric Infection withYersinia pseudotuberculosis

Abstract

The gross and microscopic pathologic changes in 70 cases of serologically proven enteric infections with Yersinia pseudotuberculosis are presented. The highest incidence was in young males, and the commonest infecting organism belonged to serologic O-group I. Clinically, the illness resembled acute appendicitis, but the most consistent finding at laparotomy was mesentric lymphadenitis. Surgical specimens examined included 69 mesenteric lymph nodes, 18 appendices, five terminal ileums, and two ascending colons. Histologically, four stages of the disease were identified, leading to the formation of characteristic granulomas with central necrosis and microabscess formation. Ulceration of the intestinal and appendicular mucosa may occur. The illness usually runs a benign course, and antibiotic treatment is rarely necessary. The pathogenesis and differential diagnosis are discussed with reference to the current literature.

Peripheral cell-mediated immune response to mycobacterial antigens in inflammatory bowel disease

“…Although mycobacteriae are a classical cause of granulomata, other microorganisms can also cause granulomatous reactions in man. An example would be Y. pseudotuhcrculo.sis [33]. and one group has reported increased cell-mediated immune responses to a related species, Y.…”

Clinical role for a superantigen in Yersinia pseudotuberculosis infection.

“…The mechanisms by which the organism mediates these symptoms are poorly understood. However, the preferential avidity for lymphoid tissues seen in this bacterium and the characteristic histopathological finding of lymphoid hyperplasia mainly seen in mesenteric lymph nodes (9,10) suggest that the stimulation of a large proportion of T cells may be involved in the pathogenesis of this infection.…”

The Response Regulator PhoP of Yersinia pseudotuberculosis Is Important for Replication in Macrophages and for Virulence

“…pseudotuberculosis is typically transmitted via the fecaloral route (13). The bacteria can cross the intestinal barrier through M cells and reach the underlying Peyer's patches.…”