2007
DOI: 10.1242/dev.02622
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Abstract: Tbx5 is essential for initiation of the forelimb, and its deletion in mice results in the failure of forelimb formation. Misexpression of dominant-negative forms of Tbx5 results in limb truncations,suggesting Tbx5 is also required for forelimb outgrowth. Here we show that Tbx5 is expressed throughout the limb mesenchyme in progenitors of cartilage, tendon and muscle. Using a tamoxifeninducible Cre transgenic line, we map the time frame during which Tbx5 is required for limb development. We show that deletion o… Show more

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Cited by 76 publications
(82 citation statements)
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“…Recent results from the same lab show that post-initiation ablation of Tbx5 function using a conditional allele does not result in limb truncations or loss of Fgf10 (Hasson et al, 2007). Instead, reduction of the forelimb along the anteroposterior axis is seen early in forelimb development, analogous to the thinner hindlimbs seen in our corresponding Tbx4 study.…”
Section: A Model For Tbx4 and Tbx5 Function In The Limbsupporting
confidence: 76%
“…Recent results from the same lab show that post-initiation ablation of Tbx5 function using a conditional allele does not result in limb truncations or loss of Fgf10 (Hasson et al, 2007). Instead, reduction of the forelimb along the anteroposterior axis is seen early in forelimb development, analogous to the thinner hindlimbs seen in our corresponding Tbx4 study.…”
Section: A Model For Tbx4 and Tbx5 Function In The Limbsupporting
confidence: 76%
“…Both studies reach identical conclusions: Tbx4 and Tbx5 are required during the initial phase of limb initiation but are dispensable for continued limb outgrowth (Hasson et al, 2007;Naiche and Papaioannou, 2007) (Fig. 2B).…”
Section: Tbx4 and Tbx5 Have Temporally Distinct Roles During Limb Devsupporting
confidence: 56%
“…Once limb buds have initiated, it is expressed broadly in the limb mesenchyme. Yet as limbs develop, its expression becomes more restricted, and by E12.5 Tbx5 expression can be observed in the MCT, few skeletal elements, tendons, and other connective tissues (Hasson et al, 2007). Because at these postinitiation stages Tbx5 does not have an apparent function in the skeleton nor in the muscles (Hasson et al, 2007(Hasson et al, , 2010, it serves as a good target to address MCT early roles in limb muscle patterning.…”
Section: Muscle Connective Tissue Organizationmentioning
confidence: 99%