Syngap1regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex
Ruggiero Francavilla,
Bidisha Chattopadhyaya,
Jorelle Linda Damo Kamda
et al.
Abstract:SYNGAP1 haploinsufficiency-related intellectual disability (SYNGAP1-ID) is characterized by moderate to severe ID, generalized epilepsy, autism spectrum disorder, sensory processing dysfunction and other behavioral abnormalities. While most studies, so far, have focussed on the role of Syngap1 in cortical excitatory neurons, recent studies suggest that Syngap1 plays a role in GABAergic inhibitory neuron development as well. However, the molecular pathways by which Syngap1 acts on GABAergic neurons, and whether… Show more
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