2006
DOI: 10.1111/j.1365-2958.2006.05099.x
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Abstract: SummaryDental plaque biofilm formation proceeds through a developmental pathway initiated by the attachment of pioneer organisms, such as Streptococcus gordonii, to tooth surfaces. Through a variety of synergistic interactions, pioneer organisms facilitate the colonization of later arrivals including Porphyromonas gingivalis , a potential periodontal pathogen. We have investigated genes of S. gordonii required to support a heterotypic biofilm community with P. gingivalis . By screening a plasmid integration li… Show more

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Cited by 125 publications
(121 citation statements)
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“…For example, using fluorescently stained cells, it was observed that P. gingivalis colonized in vitro biofilms of S. gordonii especially in regions where the latter organisms accumulated (103). This observation is consistent with the known interactions between these two organisms as described above.…”
Section: Bacterial Interactions Influence the Localization Of Residensupporting
confidence: 76%
“…For example, using fluorescently stained cells, it was observed that P. gingivalis colonized in vitro biofilms of S. gordonii especially in regions where the latter organisms accumulated (103). This observation is consistent with the known interactions between these two organisms as described above.…”
Section: Bacterial Interactions Influence the Localization Of Residensupporting
confidence: 76%
“…BfrAB regulates the expression of the bfrCD and bfrEFG operons, which encode two ABC transporters and a CAAX amino-terminal protease family protein. Interestingly, bfrC (ccmA) and bfrG are also required for the maturation of dual-species communities with P. gingivalis (322). As an organism that is predominantly in the biofilm mode of existence, S. gordonii may benefit from homotypic and heterotypic community-related genes being in relatively close proximity.…”
Section: Two-component Signal Transduction Systemsmentioning
confidence: 99%
“…Thus, mutations in genes encoding components of quorumsensing systems, e.g., comCDE (354); TCSS, e.g., vicRK (543); GBPs (370); and metal ion permeases (503) can impair S. mutans biofilm formation. Optimal biofilm formation by S. gordonii and S. sanguinis also requires multiple gene products including sortase (428) and proteins involved with ␤-glucoside metabolism and carbon catabolite control (296,364), nucleotide biosynthesis (181), oxidative stress (322,363), and environmental sensing and signaling (193). The growth of nonmitis-group streptococci as biofilms is only just beginning to be studied, but the complexities of M serotypes, capsular serotypes, and the expression of pilus types and antigenically variable surface proteins will probably make interpretations of the molecular pathways involved extremely difficult.…”
Section: Biofilm Formationmentioning
confidence: 99%
“…Changes in biofilm ecology can lead to diseases such as inflammatory bowel disease (28), vaginitis (12), and caries (46). Interactions between the bacterial species that reside in the biofilm influence the composition of the communities (21,45), a process termed bacterial interference (16). As a consequence, changes in the populating species influence whether the biofilm favors either a benign or otherwise beneficial homeostatic state or the development of disease.…”
mentioning
confidence: 99%