<i>Staphylococcus lugdunensis</i> sepsis and endocarditis in a newborn following lotus birth

Ittleman, Benjamin R.; Szabo, Joanne S

doi:10.1017/s1047951118001300

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…Similar to many reports of invasive infections caused by SL in adults [5,[29][30][31][32] and a few case reports in children [12,13,33], in our study population two cases were identified. This is consistent with previous studies describing a fulminant course of infection as rapidly progressive endocarditis and CLABSI [34].…”

Section: Discussionsupporting

confidence: 89%

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The role of Staphylococcus lugdunensis as a pathogen in children: a multicentre retrospective study

Hurvitz

Cahan

Gross

et al. 2021

Journal of Medical Microbiology

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Introduction: Staphylococcus lugdunensis (SL), a tube coagulase negative Staphylococcus , is known to be pathogenic in adults, causing mainly skin infections. Gap Statement: Previous studies assessing SL's role in paediatric populations are sparse and are mainly limited to case reports. Aim: Present the clinical characteristics consistent with SL infections and its putative role as a pathogen in the paediatric population. Methodology: A retrospective multicentre study was conducted in four paediatric medical centres in Israel. Patients with isolates of SL presenting between 2009–2019 were included. Results: SL was isolated from 40 patients. Average (±SD) age at presentation was 5.9 (±6.2) years, with 22 (55 %) being female. Skin, soft tissue and musculoskeletal infections were the most common (n=20, 50%) followed by ear infections (n=13, 32.5%). Five cases of urine isolates and two isolates from blood culture samples were also reported. Skin abscess was the most common infection among skin and soft tissue isolates, reported in 17 children (85%) with SL being the only pathogen in 15 (75%). Otitis media was the most common ear infection accounting for 12 (92%) of all cases with SL as the only isolate reported in 6 (46%). Five cases of SL isolates from urine specimens were reported, all of which with poor growth of bacteria and normal urinalysis. Two cases of SL growth in blood culture were found in children presenting with signs and symptoms consistent with invasive blood stream infection. Conclusions: In the paediatric population, studied infections caused by SL are increasingly observed. The results of this study highlight its role as a pathogen in soft tissue infections and its putative role in otitis media and invasive blood stream infections. However, the role of SL as an uropathogen was not established.

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Section: Discussionsupporting

confidence: 89%

“…Previous studies of SL infections in children are limited to case reports, with results from a small series doubting its role as a pathogen [10]. When SL was considered the causative agent of infection, it mostly involved bloodstream infections [11][12][13][14], skin infections [15] and foreign body related infections [16].…”

Section: Introductionmentioning

confidence: 99%

The role of Staphylococcus lugdunensis as a pathogen in children: a multicentre retrospective study

Hurvitz

Cahan

Gross

et al. 2021

Journal of Medical Microbiology

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“…However, despite the relatively low level of virulence, immature infants with sepsis caused by these pathogens present a wide range of clinical symptoms ( Lauterbach et al 2016 ). It was shown that S. lugdunensis was responsible for sepsis and endocarditis on the 1st day of life in a term newborn, which underwent lotus birth ( Ittleman and Szabo 2018 ). In contrast, S. aureus strains often exhibit a vast arsenal of toxins and enzymes involved in staphylococcal pathogenesis.…”

Section: Pathogenicity Of Staphylococcal Bloodstream Infectionsmentioning

confidence: 99%

Epidemiology and Pathogenesis of Staphylococcus Bloodstream Infections in Humans: a Review

Lisowska-Łysiak

Lauterbach

Międzobrodzki

et al. 2021

Polish Journal of Microbiology

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Staphylococci are among the most frequent human microbiota components associated with the high level of bloodstream infection (BSI) episodes. In predisposed patients, there is a high risk of transformation of BSI episodes to sepsis. Both bacterial and host factors are crucial for the outcomes of BSI and sepsis. The highest rates of BSI episodes were reported in Africa, where these infections were up to twice as high as the European rates. However, there remains a great need to analyze African data for comprehensive quantification of staphylococcal BSI prevalence. The lowest rates of BSI exist in Australia. Asian, European, and North American data showed similar frequency values. Worldwide analysis indicated that both Staphylococcus aureus and coagulase-negative staphylococci (CoNS) are the most frequent BSI agents. In the second group, the most prevalent species was Staphylococcus epidermidis, although CoNS were not identified at the species level in many studies. The lack of a significant worldwide decrease in BSI episodes indicates a great need to implement standardized diagnostic methods and research etiological factors using advanced genetic methods.

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“…The specific incidence of S. lugdunensis among the neonatal population is unknown, although CONS is the most prevalent infection among the VLBW infants in the neonatal intensive care setting. Our patient is the fourth case of S. lugdunensis sepsis in the neonatal population reported so far [ 12 , 13 , 14 ] (see Table 3 ). The uniqueness of our patient’s disease is due to the fulminant presentation with septic shock needing inotropes, as well as persistent bacteremia with an infected aortic thrombus probably from a previously placed UAC.…”

Section: Discussionmentioning

confidence: 94%

Staphylococcus lugdunensis Bacteremia with an Infected Aortic Thrombus in a Preterm Infant

Mani

Chandrasekharan

2022

Children

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Staphylococcus lugdunensis is a rare cause of late-onset sepsis in preterm infants. To our best knowledge, we report the fourth case of a male preterm infant who developed fulminant late-onset sepsis due to Staphylococcus lugdunensis with persistent bacteremia secondary to an infected aortic thrombus confirmed with two positive blood cultures. Our patient was an extremely low birth weight growth-restricted infant born at 27 weeks gestation and initially required an umbilical arterial catheter for blood pressure and blood gas monitoring. The course of this neonate was complicated by severe respiratory distress syndrome that evolved into chronic lung disease along with multiple episodes of tracheitis. Hemodynamically, the infant had a significant patent ductus arteriosus, and an episode of medical necrotizing enterocolitis followed by Staphylococcus lugdunensis septicemia. He was diagnosed with an infected aortic thrombus, probably the occult focus responsible for the persistent bacteremia. After a 6-week course of intravenous antibiotics and 4-week course of anticoagulant therapy, the infant responded and recovered without complications.

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Staphylococcus lugdunensis sepsis and endocarditis in a newborn following lotus birth

Cited by 11 publications

References 20 publications

The role of Staphylococcus lugdunensis as a pathogen in children: a multicentre retrospective study

The role of Staphylococcus lugdunensis as a pathogen in children: a multicentre retrospective study

Epidemiology and Pathogenesis of Staphylococcus Bloodstream Infections in Humans: a Review

Staphylococcus lugdunensis Bacteremia with an Infected Aortic Thrombus in a Preterm Infant

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