<i>Retracted: </i>Bone neo‐formation and mineral degradation of 4Bone.<sup>®</sup> Part <scp>II</scp>: histological and histomorphometric analysis in critical size defects in rabbits

Calvo-Guirado, José Luís; Maté-Sánchez, José E.; Delgado-Ruíz, Rafael Arcesio; Romanos, Georgios E.; Aza, Piedad N. De; Velázquez, Pablo

doi:10.1111/clr.12465

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…(Calvo‐Guirado et al. , ,b) In view of this, the results in this study were enhanced through the creation of critical defects of 6‐mm diameter, which will not close spontaneously and therefore demonstrate the regenerative potential of the biomaterials under observation (Sharifi et al. ).…”

Section: Discussionmentioning

confidence: 85%

“…The tibia defect model of the New Zealand white rabbit has been widely used (Calvo‐Guirado et al. , ,b). In addition, as an ideal scaffold material, the degradation rate of scaffolds must be appropriately coordinated with the growth rate of the new bone tissue, so as to avoid an early stress in the injured site and allow complete bone regeneration of the defects later.…”

Section: Discussionmentioning

confidence: 99%

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Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Aza

Val

Baudin

et al. 2016

Clinical Oral Implants Res

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Aza

Val

Baudin

et al. 2016

Clinical Oral Implants Res

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“…For example, the sintering process can either be used or not when preparing bone grafting substitutes to promote physicochemical effects in these materials [2,16,21]. Calcium phosphates (bioceramics) have been extensively researched and used as bone substitutes for their unique bioactive property and biocompatibility [7,22,23,24], which was why it was selected as the negative control. The degradation of materials derived from calcium phosphate takes place in vivo via dissolution and osteoclastic reabsorption process [25,26,27].…”

Section: Introductionmentioning

confidence: 99%

Study of Two Bovine Bone Blocks (Sintered and Non-Sintered) Used for Bone Grafts: Physico-Chemical Characterization and In Vitro Bioactivity and Cellular Analysis

et al. 2019

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In this work, the physicochemical properties and in vitro bioactivity and cellular viability of two commercially available bovine bone blocks (allografts materials) with different fabrication processes (sintered and not) used for bone reconstruction were evaluated in order to study the effect of the microstructure in the in vitro behavior. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, mechanical resistance of blocks, mercury porosimetry analysis, in vitro bioactivity, and cell viability and proliferation were performed to compare the characteristics of both allograft materials against a synthetic calcium phosphate block used as a negative control. The herein presented results revealed a very dense structure of the low-porosity bovine bone blocks, which conferred the materials’ high resistance. Moreover, relatively low gas, fluid intrusion, and cell adhesion were observed in both the tested materials. The structural characteristics and physicochemical properties of both ceramic blocks (sintered and not) were similar. Finally, the bioactivity, biodegradability, and also the viability and proliferation of the cells was directly related to the physicochemical properties of the scaffolds.

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“…This discrepancy may affect the material’s performance [20]. Many reviews have discussed a number of biomaterials and their manufacturing processes for biodegradable scaffold fabrication, but very little work has been done to obtain biomaterials with patient-specific degradation rates [21,22,23,24]. …”

Section: Introductionmentioning

confidence: 99%

SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

Fernández

Gehrke²,

Martı́nez

et al. 2017

Materials

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Some studies have demonstrated that in vivo degradation processes are influenced by the material’s physico-chemical properties. The present study compares two hydroxyapatites manufactured on an industrial scale, deproteinized at low and high temperatures, and how physico-chemical properties can influence the mineral degradation process of material performance in bone biopsies retrieved six months after maxillary sinus augmentation. Residual biomaterial particles were examined by field scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) to determine the composition and degree of degradation of the bone graft substitute material. According to the EDX analysis, the Ca/P ratio significantly lowered in the residual biomaterial (1.08 ± 0.32) compared to the initial composition (2.22 ± 0.08) for the low-temperature sintered group, which also presented high porosity, low crystallinity, low density, a large surface area, poor stability, and a high resorption rate compared to the high-temperature sintered material. This demonstrates that variations in the physico-chemical properties of bone substitute material clearly influence the degradation process. Further studies are needed to determine whether the resorption of deproteinized bone particles proceeds slowly enough to allow sufficient time for bone maturation to occur.

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Retracted: Bone neo‐formation and mineral degradation of 4Bone.^® Part II: histological and histomorphometric analysis in critical size defects in rabbits

Abstract: 4Bone(®) is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.

Cited by 9 publications

References 29 publications

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Study of Two Bovine Bone Blocks (Sintered and Non-Sintered) Used for Bone Grafts: Physico-Chemical Characterization and In Vitro Bioactivity and Cellular Analysis

SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

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Retracted: Bone neo‐formation and mineral degradation of 4Bone.® Part II: histological and histomorphometric analysis in critical size defects in rabbits

Abstract: 4Bone(®) is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.

Cited by 9 publications

References 29 publications

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

Study of Two Bovine Bone Blocks (Sintered and Non-Sintered) Used for Bone Grafts: Physico-Chemical Characterization and In Vitro Bioactivity and Cellular Analysis

SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

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Retracted: Bone neo‐formation and mineral degradation of 4Bone.^® Part II: histological and histomorphometric analysis in critical size defects in rabbits