Phoenix dactyliferaProtects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity

Abstract

Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine the effect of Phoenix dactylifera extract (PDE) on DOX-induced cardiotoxicity and nephrotoxicity. Experimental rats were divided into four groups, receiving normal saline 4 ml/kg, DOX alone, and crude extract of PDE at doses of 1 g/kg and 1.5 g/kg in the presence of DOX, respectively, for 21 days. Cardiac enzymes and serum and urinary sodium and potassium levels were evaluated which were analyzed statistically by using one-way ANOVA. Subsequently, DOX initiated changes in the level of cardiac markers CK-MB, LDH, and troponin I, which were notably reversed by PDE. PDE was also effective against serum and urinary sodium and urinary potassium and protected against DOX-induced nephrotoxicity. Groups treated with different doses of PDE showed marked decrease in levels of cardiac and renal markers. The study concluded that the PDE extract possesses protective effects against DOX-induced cardiotoxicity and nephrotoxicity.

Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats

“…We found no statistically significant (p > 0:05) changes in the studied electrolytes (Na + , K + , and Cl -), which was also previously reported by other authors in other animal models [22], although others have reported significant changes [23]. At this stage, we have no explanation for why cardiac troponin I (cTnI) levels were not elevated, as its values were <0.20 ng/mL in the control and MXB pretreatment groups as well as in the doxorubicin group.…”

Acute Toxicological Assessment and Investigation of Cardioprotective Potential of Processed Pumpkin (Cucurbita Maxima) Seed Flour

“…High intakes of sodium have been reported to be associated with an increased risk of cardiovascular disease especially heart disease [57]. Plasma sodium ion was elevated in rats intoxicated with DOX compared with the normal control, and there was observed a decrease in elevated ion to normal values in groups who received processed Cucurbita maxima seed flour as it was also reported previously that elevated sodium ion was seen in rats having cardiac damage [58] Atherogenic index denotes the magnitude of the potential occurrence of atherosclerosis [59]. The higher of atherogenic index, the potential occurrence of atherosclerosis.…”

Date Palm Pollen Extract Avert Doxorubicin-Induced Cardiomyopathy Fibrosis and Associated Oxidative/Nitrosative Stress, Inflammatory Cascade, and Apoptosis-Targeting Bax/Bcl-2 and Caspase-3 Signaling Pathways

“…They were also found to activate a cellular redox defense mechanism by stimulating endogenous antioxidant fractions [32] and keep the cells from xenobiotic oxidative stress, DNA impairment, and apoptosis [33]. Much attention has been given to using plant chemicals as a defensive strategy to resolve cardiotoxicity triggered by DOX [34][35][36].…”