<i>Ocimum gratissimum</i> Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats

Ajayi, Abayomi Mayowa; Ologe, Mary O.; Ben‐Azu, Benneth; Okhale, Samuel; Adzu, Bulus; Ademowo, Olusegun G.

doi:10.1515/jbcpp-2016-0096

Cited by 24 publications

(12 citation statements)

References 41 publications

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“…Applied externally, the leaves are used to treat rheumatism and lumbago (Bown, 1995). Moreover, pharmacological studies have shown that the extract and essential oil from the leaves O. gratissimum significantly reduce carrageenan-induced rat paw edema and suppress collagen-induced arthritis in rats (Ajayi et al, 2017;Madhu and Harindran, 2014;Paula-Freire et al, 2013). The traditional claims founded on ethnopharmacological information as well as in vitro and in vivo pharmacological reports of the antiinflammatory properties of O. gratissimum are undoubtedly due to numerous bioactive constituents found in the plants acting synergistically or each having its respective pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

Bioguided identification of pentacyclic triterpenoids as anti-inflammatory bioactive constituents of Ocimum gratissimum extract

Dzoyem

Nganteng

Melong

et al. 2021

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Bioguided identification of pentacyclic triterpenoids as anti-inflammatory bioactive constituents of Ocimum gratissimum extract

Dzoyem

Nganteng

Melong

et al. 2021

Journal of Ethnopharmacology

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“…Preparations were examined under a microscope with 40× magnification. The number of leukocytes was calculated by the following formula [19]:…”

Section: Leucocyte Countmentioning

confidence: 99%

“…The exudate was centrifuged at 5400 g for 10 min at 4 • C to obtained supernatant aliquoted and then stored at −8 • C [19]. TNF-α was determined using an ELISA kit (Sigma, St. Louis, MO, USA), according to the manufacturer's instructions.…”

Section: Leucocyte Countmentioning

confidence: 99%

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

2019

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Nigella sativa oil has been known to have potent anti-inflammatory activity. This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical application. The activity was checked using two methods: carrageenan-induced paw oedema and granuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa could overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%), low leucocytes count (43.55% lower than control) as well as a notable TNF-α concentration (50% lower than control) on the inflamed area. In conclusion, topical application of a Nigella sativa balm stick was effective for both acute and sub-acute forms of inflammation.

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“…Inflammatory processes are suppressed with anti-inflammatory drug in medical practice. Ethnomedical preparations improves clinical disease conditions by suppression of inflammatory processes (4)(5)(6). Helianthus annuus Linn.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and analgesic activities of methanol extract of Helianthus annuus Linn. (Asteraceae) leaf

Onoja

Onyebuchi

Ijeh

et al. 2019

The EuroBiotech Journal

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This study evaluate the anti-inflammatory and analgesic properties of Helianthus annuus Linn. in rats. Methanol extract of Helianthus annuus (HAE) leaf was used in this study. Formalin- and egg-albumin induced-paw edema were used to investigate the anti-inflammatory activities while acetic acid-induced writhing reflex and tail flick models were used to evaluate the analgesic properties. The doses of HAE used were 150, 300 and 600 mg/kg. Acetylsalicylic acid (ASA) was used as reference drug in the anti-inflammatory and writhing reflex models while pentazocine (reference drug) was used in tail flick model. The negative control was dosed 5% tween-20 (10 ml/kg). The HAE exhibited significant (P < 0.05) dose-dependent anti-inflammatory and analgesic activities. At 3 hour (h) post treatment, the HAE (300 mg/kg) produced 33.33% and 32.94% while ASA produced 36.36% and 35.29% reduction in paw volume in the formalin and egg-albumin induced paw edema models respectively when compared with negative control. In the acetic acid-induced writhing reflex, ASA and HAE (600 mg/kg) produced 67.89% and 35.78% reduction in the number of writhing, respectively when compared with the negative control. Pentazocine and HAE (300 mg/kg) caused 67.62% and 35.24% increase in pain reaction time when compared with the negative control. The study affirms the folkloric uses of Helianthus annuus in the management of pain and inflammation.

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Ocimum gratissimum Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats

Cited by 24 publications

References 41 publications

Bioguided identification of pentacyclic triterpenoids as anti-inflammatory bioactive constituents of Ocimum gratissimum extract

Bioguided identification of pentacyclic triterpenoids as anti-inflammatory bioactive constituents of Ocimum gratissimum extract

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

Anti-inflammatory and analgesic activities of methanol extract of Helianthus annuus Linn. (Asteraceae) leaf

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