<i>Mycoplasma pneumoniae</i>‐induced cutaneous disease

Schalock, Peter C.; Dinulos, James G.

doi:10.1111/j.1365-4632.2009.04154.x

Cited by 68 publications

(82 citation statements)

References 42 publications

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“…Pese a que la mayoría son leves, las complicaciones extrapulmonares son relativamente frecuentes. Se estima que 25 a 33% de los pacientes infectados presentan alguna forma cutánea de la enfermedad, aún cuando no se manifieste clínicamente la neumonía 1 . Estas manifestaciones cutáneas pueden ser leves y con resolución espontánea, o letales.…”

Section: Discussionunclassified

Pustulosis exantemática generalizada aguda asociada a Mycoplasma pneumoniae: reporte de un caso

Navarrete‐Dechent

Curi-Tuma

Moll-Manzur

et al. 2016

Rev. chil. infectol.

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Acute generalized exanthematous pustulosis associated with Mycoplasma pneumoniae infection: a case report Acute generalized exanthematous pustulosis is an uncommon skin eruption, characterized by fever and the rapid onset of disseminated, non-follicular, sterile pustules, over an erythematous skin background. It is usually classified as a severe cutaneous adverse drug reaction, whose most relevant triggers are antibiotics and anticonvulsants. However, viral and bacterial infections have also rarely been associated with this dermatosis. We report the case of a patient, who developed lesions of acute generalized exanthematous pustulosis as an extrapulmonary manifestation of Mycoplasma pneumoniae infection.

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Section: Discussionunclassified

Pustulosis exantemática generalizada aguda asociada a Mycoplasma pneumoniae: reporte de un caso

Navarrete‐Dechent

Curi-Tuma

Moll-Manzur

et al. 2016

Rev. chil. infectol.

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“…Though less common, Mycoplasma pneumoniae infection has been associated with several extrapulmonary manifestations including neurologic complications such as aseptic meningitis or encephalitis, cardiac complications such as pericarditis or myocarditis, renal complications such as glomerulonephritis or acute renal failure, and hematologic complications such as hemolysis. 1 Mycoplasma pneumoniae is also a rare but well-known cause of StevensJohnson syndrome (SJS). SJS occurs in 1% to 5% of cases of Mycoplasma pneumoniae infection.…”

Section: Discussionmentioning

confidence: 99%

“…SJS occurs in 1% to 5% of cases of Mycoplasma pneumoniae infection. 1 According to the classification by Bastuji-Garin and colleagues, 2 SJS is characterized by extensive erosion of the skin with poorly defined circular lesions and often with Case Challenge at least one mucosal surface involved. 2 Less than 10% of the body surface area is involved in epidermal detachment.…”

Section: Discussionmentioning

confidence: 99%

A 13-Year-Old Boy with Pharyngitis, Oral Ulcers, and Dehydration

Trapp¹,

Schrantz²,

Joseph-Griffin³

et al. 2013

Pediatr Ann

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A 13-year-old boy with no significant past medical history was admitted to our institution with pharyngitis, oral ulcers, and dehydration. He was well until 8 days prior to admission when he developed a fever to 103 o F and pharyngitis. He was seen by his primary care physician, who ordered a rapid strep test and throat culture, both of which were negative, so symptomatic care was recommended.Four days prior to admission the patient developed ulcers on the inside of his mouth and lips. He was seen again by his primary care physician and started on antiviral medication and ibuprofen with hydrocodone, and a herpes simplex virus-polymerase chain reaction test was ordered. Mouth pain became so severe that the patient was unable to remain adequately hydrated. He was admitted to the hospital for pain control, intravenous fluids, and further work-up.In the 2 days prior to presentation to the hospital, he developed painful lesions on the glans of his penis. Recent medication use included NyQuil (Vicks), Theraflu (Novartis), Famvir (Novartis) and Vicoprofen (Abbott). The patient denied any history of sexual activity or For diagnosis, see page 149Editor's note: Each month, this department features a discussion of an unusual diagnosis in genetics, radiology, or dermatology. A description and images are presented, followed by the diagnosis and an explanation of how the diagnosis was determined. As always, your comments are welcome via email at Pediatrics@Healio.com.

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“…Non-EF skin manifestations during M. pneumoniae infection have been reported (16,27,30,34,37). The following known triggering factors were identified in our patient: (i) LT-rich food additive consumption derived partially from uncontrolled sources and (ii) strenuous exercises.…”

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confidence: 56%

Eosinophilic Fasciitis Associated with Mycoplasma arginini Infection

et al. 2012

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Eosinophilic fasciitis (EF) with generalized sclerodermiform skin lesions developed over a 19-month period in a previously healthy 23-year-old man. Although we confirmed EF by skin histology and laboratory tests, the recurrent fevers and the clinical observation of sclerotic prepuce with urethritis indicated further bacteriological analysis by conventional microbiological and DNA-based tests. Urethra cultures were positive for an arginine-hydrolyzing mycoplasma and Ureaplasma urealyticum. The patient also had serum IgM antibodies to Mycoplasma pneumoniae using enzyme-linked immunosorbent assay (ELISA)-based qualitative detection. Mycoplasma arginini was isolated from two independent venous blood serum samples and was identified by conventional microbiological tests and sequencing of the 16S rRNA and rpoB genes (GenBank sequence accession numbers HM179555 and HM179556, respectively). M. arginini genomic DNA also was detected by species-specific PCR in the skin lesion biopsy sample. Treatment with corticosteroids and long-term courses of selected antibiotics led to remission of skin symptoms and normalization of laboratory values. This report provides the first evidence of EF associated with mycoplasma infection and the second report of human infection with M. arginini and therefore suggests that this mycoplasma infection might have contributed to the pathogenesis of the disease. CASE REPORTA 23-year-old male, a former bodybuilder, sought medical treatment for progressive generalized skin tightening. His previous medical history was unremarkable. The patient had terminated sport exercises 19 months earlier due to a sudden, progressive skin induration, which led to restricted movement of wrists and ankles within several months, and cutaneous symptoms gradually extended to the extremities and to the upper body. At the beginning of his illness, he quit body building and stopped anabolic steroid consumption. Within 1 year, he lost 23 kg, he became febrile in the afternoons, and his skin disease slowly progressed. Serological tests for HIV, hepatitis C virus (HCV), and Lyme borreliosis were negative. His crista biopsy specimen revealed eosinophilia. The patient was treated with a very low dose of prednisone (10 mg/day orally [p.o.]) for the next 6 months without dermatological improvement. Any attempt to decrease the prednisone dosage resulted in return of arthralgia and fever.Upon initial examination, the patient suffered from generalized skin tightening and tautness on his whole trunk and on all the extremities except the fingers and toes. He also exhibited multiple cutaneous venous furrowing on the arms (Fig. 1). The shiny, brownish, firm skin with some porcelain-whitish patches was tightly bound to the underlying tissues, resulting in a restricted movement of the chest, wrists, elbows, ankles, and knees. The genital region was also involved; the indurated, sclerotic, depigmented prepuce led to phimosis and showed lichen sclerosus-like symptoms with an inflamed urethral orifice.Initial laboratory tests showed periph...

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Mycoplasma pneumoniae‐induced cutaneous disease

Cited by 68 publications

References 42 publications

Pustulosis exantemática generalizada aguda asociada a Mycoplasma pneumoniae: reporte de un caso

Pustulosis exantemática generalizada aguda asociada a Mycoplasma pneumoniae: reporte de un caso

A 13-Year-Old Boy with Pharyngitis, Oral Ulcers, and Dehydration

Eosinophilic Fasciitis Associated with Mycoplasma arginini Infection

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