Mangopeel powder supplementation prevents oxidative stress, inflammation, and fibrosis in carbon tetrachloride induced hepatic dysfunction in rats

Abstract

The study reports the phenolic profiles and hepatoprotective properties of mango peel powder against carbon tetrachloride (CCl4) induced hepatic damage in rats. It was found that the mango peel possesses high amount of polyphenols and flavonoids as analyzed by HPLC‐DAD. Supplementation of mango peel powder in CCl4 administered rats exhibit strong protective effects in vivo. The results suggest that mango peel powder supplementation antagonized the CCl4‐induced increase in serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities and hepatic malondialdehyde levels. Furthermore, mango peel powder supplementation prevented decrease in antioxidant catalase activity and glutathione concentration in CCl4‐administered rats. Mango peel powder supplementation also prevented the inflammatory cells infiltration and fibrosis in liver of CCl4 treated rats. This finding demonstrates that the polyphenol‐rich mango peel powder can be explored as a chemopreventive or chemotherapeutic agent against oxidative‐stress‐related liver disorders. Practical applications Mango (Mangifera indica L.), the most important fruit in Anacardiaceae family, is a tropical fruit which possesses high nutritional and medicinal value. The research showed that mango peel possesses numerous phenolic antioxidants. The results also demonstrated that mango peel powder exerts a protective effect against carbon tetrachloride‐induced liver injury in rats. Every year, considerable amount of mango peel is produced in juice industries which are left as waste product. Thus, this project will provide a potential source of phenolic compounds and potential approach to prevent liver diseases.

Protective and therapeutic role of mango pulp and eprosartan drug and their anti-synergistic effects against thioacetamide-induced hepatotoxicity in male rats

“…This indicates that T induced liver inflammation and fibrosis, and this may be linked to the increase in lipid peroxidation. The lipid peroxidation induces over expression of cytokines and increases the synthesis of collagen which activates hepatic stellate cells (HSCs) (Rejitha et al 2012;Ulla et al 2017). The activated HSCs and immune cells induce production and secretion of TGF-β1 and PDGF-BB where the overproduction of TGF-β1 is a major cause of tissue fibrosis (Habtemariam 1997;Park et al 2016).…”

“…The mechanism of the protective and therapeutic effects of M may be related to the antioxidant activity of its contents, including phenolics and flavonoids and their gradients, carotenoids, vitamins, and some minerals. The antioxidant activities of phenolic and flavonoid compounds may be due to their ability to scavenge the ROS and their capability to up-regulate non-enzymatic and enzymatic antioxidants (López et al 2007;Mehra et al 2013;Abdel-Rahman et al 2015;Shaban et al 2016b;Ulla et al Table 4 The combination index (CI)* values for the mango pulp (M) and eprosartan drug (E) co-administration on major tested parameters GSH (glutathione), GSSG (reduced glutathione), GPx (glutathione peroxidase), SOD (superoxide dismutase), GST (glutathione-S-transferase), GSR (glutathione reductase), MDA (malonedialdehyde), TNFα (tumor necrosis factor-α), and PDGF-BB (platelet-derived growth factor-BB), and TGF-β1 (transforming growth factor-beta1 and the data are being presented as the mean ± SD * CI values determine the type of impact between E and M. the effect can be evaluated as synergism (CI < 1), anti-synergism (CI > 1), or additive (CI = 1) (Zhou et al 2007;Habashy et al 2018;Shaban et al 2020Shaban et al , 2021aShaban et al , 2022 2017). Additionally, carotenoids, vitamins as A and C, and some minerals as Zn and Cu play important roles as antioxidants.…”

“…In addition, the reduction of OS led the reduction of TNF-α, PDGF-BB, and TGF-β1 expression. It has been reported that the inhibitors of TGF-β1 may be clinically useful as anti-fibrotic agents (Rejitha et al 2012;Ulla et al 2017).…”

Effect of Thermo-Sonication and Ultra-High Pressure on the Quality and Phenolic Profile of Mango Juice

“…Mango is consumed as fresh fruit as well as processed products, like juice, pulp, powder, mash, pickles and syrup [2,3] and, among these products, juice has the higher consumption and higher economic value [2,4]. Due to a higher consumption, the mango juice market has increased considerably [5,6]. As for fruit juice processing, a number of studies have focused on the effects of processing technologies on juice quality [2,3,7,8].…”

Mangiferin and organ fibrosis: A mini review

“…Mangiferin‐riched mango peel powder supplementation inhibits inflammatory cell infiltration and fibrosis in liver of CCl4‐induced hepatic fibrosis rats. Meanwhile, it antagonizes the increase in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and hepatic malondialdehyde levels, and enhances antioxidant catalase activity in the fibrotic livers 69 . Vimang and mangiferin could protect the liver from iron induced oxidative damage via the increasing iron excretion in the liver 91 .…”