Lavandula angustifolia biological characteristics: An in vitro study

Abstract

Objective Lavender is an aromatic shrub belonging to the Lamiaceae family. The flowers and leaves in different forms of extracts are used as herbal medicine. The accumulation of amyloid beta (Aβ) plaques, reduction of acetylcholine due to hyperactivity of acetylcholinesterase, and glutamate neurotoxicity are known to be involved in decreased level of cognitive function. In our previous study, we proved that the aqueous extract of lavender improves learning and memory. This in vitro study was designed to evaluate antiaggregative, antioxidant, and antiacetylcholinesterase activities of the herbal medicine. Methods Thin layer chromatography, high‐performance liquid chromatography, thioflavin, atomic force microscope (AFM), Elleman,and 2,2‐diphenyl‐1‐picryl hydrazyl techniques were used for qualitative analysis, quantitative analysis, antiaggregative characteristics, anti‐acetylcholinestrase activity and antioxidant activity of the lavender extract, respectively. Results We found chromatographic peaks of caffeic acid and luteolin‐7‐glycosid in the lavender extract. Our results indicated that aqueous extract of lavender dose‐dependently inhibits the formation of Aβ aggregate. The AFM technique showed that lavender largely diminished the Aβ fibril formation. We also observed a considerable radical scavenging activity of the extract. Conclusions Prevention of Aβ plaque formation and antioxidant activity along with nontoxic features of the lavender extract promise possible effectiveness of this plant on improving some neurological disorders including Alzheimer's disease.

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

“…Nevertheless, data showing that the effects of lavender polar extracts are limited. In a study conducted over 10 years, Soheili and Salami demonstrated that the aqueous extract of lavender improves the impaired learning and memory, positively affect the synaptic transmission in an animal model of Alzheimer's disease (AD), clears the amyloid beta (A β ) plaques from the hippocampus of these animals, and dose dependently inhibits the formation of A β aggregate, caffeic acid ( 1 , see Figure ) and luteolin ( 5 ) were characterized as components of the aqueous extract. Danciu and coworkers investigated the in vitro antimicrobial effect against Staphylococcus aureus and the antiproliferative activity against two cancerous cell lines (A375 human melanoma and MDA‐MB‐231 breast carcinoma) of Mentha×piperita L. and Lavandula angustifolia Mill .…”

Protective role of luteolin against bisphenol A‐induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO‐1 pathway

“…As indicated in the reported literature, natural compounds extricated from plants have noteworthy defensive and preventive effects against pathological conditions. Luteolin (Lut), 3′,4′,5,7‐tetrahydroxyflavone, is a main participant of the flavonoid family and normally found in glycosylated forms in basic perilla leaf, green pepper, celery, seed, honeysuckle bloom, and chamomile blossom . It produces numerous restorative properties, for example, wound healing and antioxidant, anti‐inflammatory, antidiabetic, and anticancer activities.…”

Photothermal Therapy with HER2-Targeted Silver Nanoparticles Leading to Cancer Remission

“…Lavandula angustifolia Mill. is a widely used plant in biotechnology that can be grown in a large quantities under in vitro conditions to obtain a batch-to-batch reproducible aqueous extract [ 34 ].…”