“…Growing epidemiological evidence indicates that common variants of the TGF-b pathway receptors that alter TGF-b signalling can modify cancer risk . Two common alleles in the TGFBR1 gene, TGFBR1*6A and Int7G24A, A allele, which reside in exon 1 and intron 7, respectively, have been reported to act as low-penetrance tumour susceptibility alleles (Chen et al, , 2004(Chen et al, , 2006Pasche et al, 1999Pasche et al, , 2004Baxter et al, 2002;Kaklamani et al, 2003;Zhang et al, 2003;Bian et al, 2005;Kaklamani and Pasche, 2005). TGFBR1*6A has a deletion of three alanines within a stretch of nine alanines.…”