2006
DOI: 10.1158/1078-0432.ccr-05-1518
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Purpose: The transforming growth factor-h (TGF-h) signaling pathway has been frequently implicated in breast cancer. An intronic variant (Int7G24A) of TGF-h receptor type I (TGFBR1) is associated with kidney and bladder cancers in our recent study.We hypothesize that this germline variant may be involved in development and progression of breast cancer. Experimental Design: Case-control studies were designed from archived paraffin-embedded tissue specimens from the same geographic area with a homogenous ethnic … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
49
0
2

Year Published

2006
2006
2013
2013

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 55 publications
(51 citation statements)
references
References 41 publications
0
49
0
2
Order By: Relevance
“…In addition, mutations of downstream TGF-b signalling pathway genes have also been shown to result in a loss of responsiveness to TGF-b1 (Wang et al, 2000;Maliekal et al, 2003). In contrast to many other tumours, structural lesions of TGFb signal transducers appear to be rare in breast cancers (Chen et al, 1998;Xie et al, 2002;Jeruss et al, 2003). This suggests that, in a number of circumstances such as cell dedifferentiation, the normal function of TGFb1 in breast epithelial cells might be abrogated on behalf of oncogenic function.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, mutations of downstream TGF-b signalling pathway genes have also been shown to result in a loss of responsiveness to TGF-b1 (Wang et al, 2000;Maliekal et al, 2003). In contrast to many other tumours, structural lesions of TGFb signal transducers appear to be rare in breast cancers (Chen et al, 1998;Xie et al, 2002;Jeruss et al, 2003). This suggests that, in a number of circumstances such as cell dedifferentiation, the normal function of TGFb1 in breast epithelial cells might be abrogated on behalf of oncogenic function.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, virally transformed tumorigenic mammary epithelial cell lines as well as most of the cell lines derived from invasive human breast carcinomas are resistant to the antiproliferative effects of TGFb1 in vitro and do not respond to treatment with TGFb1 in vivo. In a number of cases, this is attributable to inhibiting mutations in either TGFb type I or II receptors (Chen et al, 1998;Gobbi et al, 2000) or deregulation of the downstream signalling cascade (Xie et al, 2002).…”
mentioning
confidence: 99%
“…This variant has been reported to be associated with NSCLC, kidney and bladder cancer susceptibility (Zhang et al, 2003;Chen et al, 2004). Patients with invasive and metastatic breast cancer have been reported to have a higher frequency of Int7G24A, and this variant may represent a marker for breast cancer progression (Chen et al, 2006). No studies have to date been published on this variant in familial breast cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Growing epidemiological evidence indicates that common variants of the TGF-b pathway receptors that alter TGF-b signalling can modify cancer risk . Two common alleles in the TGFBR1 gene, TGFBR1*6A and Int7G24A, A allele, which reside in exon 1 and intron 7, respectively, have been reported to act as low-penetrance tumour susceptibility alleles (Chen et al, , 2004(Chen et al, , 2006Pasche et al, 1999Pasche et al, , 2004Baxter et al, 2002;Kaklamani et al, 2003;Zhang et al, 2003;Bian et al, 2005;Kaklamani and Pasche, 2005). TGFBR1*6A has a deletion of three alanines within a stretch of nine alanines.…”
mentioning
confidence: 99%
See 1 more Smart Citation