2020
DOI: 10.1177/0748233720937201
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Abstract: Silver nanoparticles (Ag NPs) are widely used in nanomedicine, pharmaceutical products, industry and other consumer products owing to their unique physiochemical properties with probable potential risk to human health and the ecosystems. The aim of this work was to investigate the in-life morphological effects, biochemical, histological and histochemical alterations that might be induced by variable sizes of Ag NPs in hepatic, renal and testicular tissues with the hypothesis that variable sizes of nano-Ag coul… Show more

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Cited by 11 publications
(9 citation statements)
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References 56 publications
(64 reference statements)
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“…The BW of mice injected with high dose of IONPs (26.97 ± 0.34 g) on the first day were equivalent to the control group (26.87 ± 0.43 g), and on the 28th day, the BW of mice administrated with high-dose IONPs (38.57 ± 1.22 g) were even slightly heavier than the control group (36.29 ± 0.54 g), which exhibited their negligible systemic toxicity in vivo. It is well-established that water intake and food consumption of experimental animals are also classical indexes to reveal the possible systematic toxicity [ 24 , 43 , 44 ]. Thus, we have continuously monitored water intake and food consumption of mice after low-, middle- and high-dose IONPs administration.…”
Section: Resultsmentioning
confidence: 99%
“…The BW of mice injected with high dose of IONPs (26.97 ± 0.34 g) on the first day were equivalent to the control group (26.87 ± 0.43 g), and on the 28th day, the BW of mice administrated with high-dose IONPs (38.57 ± 1.22 g) were even slightly heavier than the control group (36.29 ± 0.54 g), which exhibited their negligible systemic toxicity in vivo. It is well-established that water intake and food consumption of experimental animals are also classical indexes to reveal the possible systematic toxicity [ 24 , 43 , 44 ]. Thus, we have continuously monitored water intake and food consumption of mice after low-, middle- and high-dose IONPs administration.…”
Section: Resultsmentioning
confidence: 99%
“…investigated chronic toxicity of low-dose exposure to five distinct sizes of AgNPs (10, 20, 40, 60 and 100 nm) in male BALB/c mice receiving multiple daily IP injection (1 mg/kg b.w.) [ 73 ]. Their findings also indicated that smaller AgNPs would be more toxic than larger counterparts; IP injected AgNPs could evoke prominent histological and histochemical alterations in hepatic, renal and testicular tissues.…”
Section: Discussionmentioning
confidence: 99%
“…These results were further supported by the S and G2/M phase accumulations, which were potentially correlated with DNA repair and preventing of incorrect chromosome segregation (Medina-Reyes et al, 2015; Panzarini et al, 2017). The toxicity of AgNPs has been reported to be directly related with their particle size, shape, aggregation, and chemical coating (Al-Doaiss et al, 2020; Tortella et al, 2020). However, in the present study, the induced genetic damage in HepG2 and A549 cells exhibited different relationships with physicochemical characterization of AgNPs.…”
Section: Discussionmentioning
confidence: 99%