<i>In vivo</i> biometric evaluation of Schlemm's canal with spectral‐domain optical coherence tomography in pseuduexfoliation glaucoma

İmamoğlu, Serhat; Sevim, Mehmet Şahin; Alpogan, Okşan; Erçalık, Nimet Yeşim; Kumral, Esra Türkseven; Pekel, Gökhan; Bardak, Handan

doi:10.1111/aos.13080

Cited by 27 publications

(16 citation statements)

References 21 publications

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“…ird, exfoliation may promote scar formation in the filtering area. Iris angiopathy and destruction of the blood-aqueous barrier can cause postoperative cellulose-like exudation, and neovascularization of the iris can cause intraoperative or postoperative hyphema [19,20]. In this study, one case of hyphema was found after PXG surgery.…”

Section: Discussionmentioning

confidence: 54%

The Effects of Trabeculectomy on Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma

Tang

Zhang

et al. 2020

Journal of Ophthalmology

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Purpose. To compare long-term effects of trabeculectomy on pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG). Methods. This retrospective case-control study included 53 eyes of PXG and 76 eyes of POAG. Intraocular pressure (IOP), number of antiglaucoma medications used, surgical success rate, and occurrence of complications were observed and statistically analyzed in both groups at 3 and 6 months and at 1, 3, and 5 years after trabeculectomy. Surgical success was defined according to the following 3 criteria: (1) IOP ≤ 21 mmHg; (2) IOP ≤ 18 mmHg; (3) IOP ≤ 15 mmHg. Complete success is defined as patients met these criteria without medical treatment, and qualified success is defined as patients met these criteria with medical treatment (≤3 medications). Cumulative probabilities of success were compared using the Kaplan–Meier survival analysis. Results. For the 3 criteria, there were no statistically significant differences in complete and qualified success rates between the two groups at 3 and 6 months after trabeculectomy (P>0.05). For criterion A, complete success rates in PXG at 3 and 5 years after surgery were lower than those in POAG; for criterion B, complete and qualified success rates in PXG at 3 and 5 years after surgery were lower than those in POAG; for criterion C, complete and qualified success rates in PXG at 1, 3, and 5 years after surgery were lower than those in POAG, the differences were statistically significant (P<0.05). Conclusions. The short-term success rates of both types of glaucoma were similar; however, the long-term success rate of PXG was significantly lower, and it was difficult to achieve long-term control of IOP at a low target level.

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Section: Discussionmentioning

confidence: 54%

The Effects of Trabeculectomy on Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma

Tang

Zhang

et al. 2020

Journal of Ophthalmology

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“…() reported larger SC cross‐sectional areas (13 991 ± 1357 μ m 2 ) for healthy Chinese adults, while Imamoglu et al. () described smaller values of 5000 μ m 2 measured by OCT in healthy Turkish adults. The possibility that, besides the measurement method, ethnicity could explain some of the differences observed needs to be explored.…”

Section: Discussionmentioning

confidence: 97%

“…Accordingly, Imamoglu et al. () found that both SC length and area did not correlate with factors such as axial length and anterior chamber depth. However, we did detect a significant link, although with a mild correlation, between SC diameter and age.…”

Section: Discussionmentioning

confidence: 98%

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Fernández‐Vigo

Kudsieh²,

De‐Pablo‐Gómez‐de‐Liaño

et al. 2018

Acta Ophthalmologica

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Purpose To measure the Schlemm's canal (SC) in vivo by Fourier‐domain optical coherence tomography (FD‐OCT) in a Caucasian paediatric population. Methods Participants of this cross‐sectional study were 290 healthy children. In the right eye of each child, SC cross‐sectional diameter and area measurements were made with the FD‐OCT instrument RTVue® (Optovue Inc, Fremont, CA, USA) in the nasal and temporal quadrants. These SC variables were then assessed for correlation with the factors age, gender, refractive error, anterior chamber angle and trabecular meshwork (TM) metrics. Finally, the reproducibility of the SC measurements was assessed in 30 of the participants. Results Mean participant age was 10.7 ± 3.4 years (range 3–18). SC diameters could be measured in both quadrants in 70.6% and 70.4% of subjects, respectively. Mean SC diameters were similar (p = 0.125) for the temporal and nasal quadrants: 266.7 ± 84.1 μm (range 131–509) and 273.2 ± 77.3 μm (range 124–486), respectively. Mean SC areas were also similar (p = 0.167) for the two quadrants: 9975 ± 3514 μm2 (range 4000–23 000) versus 9688 ± 3297 μm2 (range 3000–24 000). No differences were detected in SC measurements according to gender, refractive error or angle and TM measurements (R ≤ 0.116; p ≥ 0.125). The exception was age which was directly correlated with SC size (p ≤ 0.041). The reproducibility of the SC measurements was excellent (intraclass correlation coefficients ≥0.936). Conclusion FD‐OCT allows the identification of the SC in children. Our data indicate an increase in SC size produced with age.

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“…17,18 Researchers have used OCT to investigate properties of SC in vivo in mice and humans. 17,[19][20][21][22][23][24][25][26] These studies were limited in axial resolution (2-5 μm) and field of view (0.5-3 mm). Imaging the detailed structure of SC in mice requires overcoming several hurdles.…”

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confidence: 99%

In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT

Zhou

Beckmann

Miller

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To validate the ability of visible-light optical coherence tomography (vis-OCT) in imaging the full Schlemm's canal (SC) and its surrounding limbal vascular network in mice in vivo through a compound circumlimbal scan. METHODS.We developed an anterior segment vis-OCT system and a compound circumlimbal scanning method, which montages eight rotated raster scans. We calibrated the circumlimbal scan geometry using a three-dimensional printed phantom eyeball before imaging wild-type C57BL/6J mice. We measured SC size by segmenting SC cross sections from vis-OCT B-scan images and imaged the limbal microvascular network using vis-OCT angiography (vis-OCTA). To introduce changes in SC size, we used a manometer to adjust the intraocular pressure (IOP) to different levels. To create additional optical scattering contrast to enhance SC imaging, we surgically increased the episcleral venous pressure (EVP) and caused blood reflux into SC. RESULTS.Using the compound circumlimbal scan, our anterior segment vis-OCT noninvasively imaged the full SC and limbal microvascular network in mouse for the first time. We observed an average 123% increase in SC volume when we decreased the IOP by 10 mm Hg from the baseline IOP of 7 to 10 mm Hg and an average 72% decrease in SC volume when the IOP level was elevated by 10 mm Hg from the baseline IOP. We also observed location-dependent SC size responses to IOP changes. Blood reflux caused by increased EVP enabled vis-OCTA to directly visualize SC, which matched well with the segmented SC. CONCLUSIONS.Vis-OCT and vis-OCTA can accurately image the entire SC and limbal microvascular network in vivo using the compound circumlimbal scan. Vis-OCT is also able to quantitatively measure SC responses to changing IOP levels.

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In vivo biometric evaluation of Schlemm's canal with spectral‐domain optical coherence tomography in pseuduexfoliation glaucoma

Abstract: Anterior segment spectral-domain optical coherence tomography offers non-invasive, in vivo measurement of the SC, and it could be used for investigating the SC changes in patients with PEX glaucoma.

Cited by 27 publications

References 21 publications

The Effects of Trabeculectomy on Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma

The Effects of Trabeculectomy on Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT

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