In vitro transfection efficiencies of T-shaped spermine-based cationic lipids with identical and nonidentical tails under high serum conditions

Abstract

T-shape spermine-based cationic lipids with identical and nonidentical hydrophobic tails having variable carbon length (from C10 to C18) were designed and synthesized. These lipids were characterized, and structure-activity relationships were...

Synthesis, gene transfection efficiency, and serum compatibility of β-sitosterol-based cationic lipids with different headgroups

“…8c and f). These results suggest that the β-sitosterol-based cationic liposome 1B /DOPE with sperminium 60,61 headgroup can provide some degree of protection to DNA under 10% and 40% FBS over 24 h.…”