In vitrosusceptibility ofMycobacterium tuberculosisto extracts ofEucalyptus camaldulensisandEucalyptus torellianaand isolated compounds

Lawal, Temitope O.; Adeniyi, Bolanle A.; Adegoke, A O; Franzblau, Scott G.; Mahady, Gail B.

doi:10.3109/13880209.2011.625953

Cited by 25 publications

(20 citation statements)

References 25 publications

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“…This could be due the bioactive tannins and saponins present in the extracts. This report agrees with the previous reports of hexane, chloroform, methanol extracts of E. camaldulensis [32,33]. In Ethiopia, the present work demonstrates antimycobacterial properties of these plants having therapeutic value in the treatment of TB.…”

Section: Resultssupporting

confidence: 93%

In vitro Anti-mycobacterial activity of selected medicinal plants against Mycobacterium tuberculosis and Mycobacterium bovis Strains

Gemechu

Giday

Worku

et al. 2013

BMC Complement Altern Med

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BackgroundTuberculosis (TB) is a global burden with one –third of the world’s population infected with the pathogen Mycobacterium tuberculosis complex and annually 1.4 million deaths occur due to the disease. This high incidence of infection and the increased rate of multi-drug resistant and extensively-drug resistant strains of the organism further complicated the problem of TB control and have called for an urgent need to develop new anti-TB drugs from plants. In this study, the in vitro activity of root of Calpurnia aurea, seeds of Ocimum basilicum, leaves of Artemisia abyssinica, Croton macrostachyus, and Eucalyptus camaldulensis were evaluated against M. tuberculosis and M. bovis strains.MethodsFive Ethiopian medicinal plants, root of Calpurnia aurea, seeds of Ocimum basilicum, leaves of Artemisia abyssinica, Croton macrostachyus, and Eucalyptus camaldulensis used locally for the management of TB. They were investigated for in vitro antimycobacterial activity against M. tuberculosis and M. bovis strains. 80% methanolic extracts of the plant materials were obtained by maceration. The antimycobacterial activity was determined using 96 wells of microplate with the help of visual Resazurin Microtiter Assay.ResultsThe crude 80% methanolic extracts of the root of C. aurea, seeds of O. basilicum, and leaves of A. abyssinica, C. macrostachyus, and E. camaldulensis had anti-mycobacterial activity with minimum inhibitory concentration (MIC) ranging from 6.25–100 μg/mL. The MIC of 80% methanol extracts in the order mentioned above ranged 25-100 μg/ml and 12.5-75 μg/mL, 25–100 μg/mL and 25–50 μg/mL, 6.25-50 μg/mL and 12.5-50 μg/mL, 12.5-100 μg/mL and 18.25-50 μg/mL and 6.25-50 μg/mL and 12.5-50 μg/mL, respectively for M. tuberculosis and M. bovis strains.ConclusionsThe results support the local use of these plants in the treatment of TB and it is suggested that these plants may have therapeutic value in the treatment of TB. However, further investigations are needed on isolating chemical constituents responsible for eliciting the observed activity in these plants.

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Section: Resultssupporting

confidence: 93%

In vitro Anti-mycobacterial activity of selected medicinal plants against Mycobacterium tuberculosis and Mycobacterium bovis Strains

Gemechu

Giday

Worku

et al. 2013

BMC Complement Altern Med

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“…in range 0.25-1.0 mg/mL, and even lower for B. subtilis, P. acnes and B. agri (MICs 0.10-0.79 mg/mL). Interestingly, generally highly resistant M. tuberculosis was sensitive to methanol, n-hexane or chloroform extract with MICs in range 0.004-0.064 mg/mL, while M. bovis was slightly less sensitive with MICs 0.01-0.05 mg/mL (Lawal et al, 2012;Gemechu et al, 2013).…”

Section: Antibacterial Effectmentioning

confidence: 99%

Antimicrobial activity of Eucalyptus camaldulensis Dehn. plant extracts and essential oils: A review

Sabo

Knežević

2019

Industrial Crops and Products

159

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A B S T R A C TEucalyptus has become one of the world's most widely planted genera and E. camaldulensis (The River Red Gum) is a plantation species in many parts of the world. The plant traditional medical application indicates great antimicrobial properties, so E. camaldulensis essential oils and plant extracts have been widely examined. Essential oil of E. camaldulensis is active against many Gram positive (0.07-1.1%) and Gram negative bacteria (0.01-3.2%). The antibacterial effect is confirmed for bark and leaf extracts (conc. from 0.08 μg/mL to 200 mg/ mL), with significant variations depending on extraction procedure. Eucalyptus camaldulensis essential oil and extracts are among the most active against bacteria when compared with those from other species of genus Eucalyptus. The most fungal model organisms are sensitive to 0.125-1.0% of E. camaldulensis essential oil. The extracts are active against C. albicans (0.2-200 mg/mL leaf extracts and 0.5 mg/mL bark extracts), and against various dermatophytes. Of particular importance is considerable the extracts' antiviral activity against animal and human viruses (0.1-50 μg/mL). Although the antiprotozoal activity of E. camaldulensis essential oil and extracts is in the order of magnitude of concentration several hundred mg/mL, it is considerable when taking into account current therapy cost, toxicity, and protozoal growing resistance. Some studies show that essential oils' and extracts' antimicrobial activity can be further potentiated in combinations with antibiotics (beta-lactams, fluorochinolones, aminoglycosides, polymyxins), antivirals (acyclovir), and extracts of other plants (e.g. Annona senegalensis; Psidium guajava). The present data confirm the river red gum considerable antimicrobial properties, which should be further examined with particular attention to the mechanisms of antimicrobial activity.limited number of antiprotozoal and antiviral agents (El-Taweel, 2015;Irwin et al., 2016). This highlights the necessity for examination of new antimicrobial agents and treatment strategies of infections caused by the mentioned microorganisms.The plant kingdom represents the source of various medicines. Indeed, since ancient times medicinal plants play an important role of health care population and could represent a significant source of new antimicrobial drugs for combating pan-and multi-drug resistant microorganisms. These new antimicrobial agents could be hidden in medicinal plant extracts and essential oils. One of the significant medicinal plants is Eucalyptus camaldulensis. Thus, this review represents the summary of previous researches data, regarding chemical composition, antimicrobial activity, and other significant effects of Eucalyptus camaldulensis.

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“…Spectroscopic characterization led to the identification of two compounds, hydroxymyristic acid methylester and a substituted pyrenyl ester, a sterol. These two compounds had MIC of 49.45 and 46.99 µg/ml; IC 50 >100 and 38.21 µg/ml; selectivity index (SI) >2.02 and 0.81, respectively, and a minimum bactericidal concentration of 62.50 µg/ml [152].Essential oil of the leaves of Eucalyptus camaldulensis possessed high antibacterial effects against Gram positive and negative bacteria with inhibition zones ranged from 9.3 to 12.5 Mm. The same effect was observed against yeast (21% inhibition) and fungi (10% inhibition) [135].…”

Section: Antimicrobial Effectmentioning

confidence: 99%

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Eucalyptus species grown in Iraq were included Eucalyptus bicolor (Syn: Eucalyptus largiflorens), Eucalyptus griffithsii, Eucalyptus camaldulensis (Syn: Eucalyptus rostrata) Eucalyptus incrassate, Eucalyptus torquata and Eucalyptus microtheca (Syn: Eucalyptus coolabahs). Eucalypts contained volatile oils which occurred in many parts of the plant, depending on the species, but in the leaves that oils were most plentiful. The main constituent of the volatile oil derived from fresh leaves of Eucalyptus species was 1,8-cineole. The reported content of 1,8-cineole varies for 54-95%. The most common constituents co-occurring with 1,8-cineole were limonene, α-terpineol, monoterpenes, sesquiterpenes, globulol and α , β and ϒ-eudesmol, and aromatic constituents. The pharmacological studies revealed that Eucalypts possessed gastrointestinal, antiinflammatory, analgesic, antidiabetic, antioxidant, anticancer, antimicrobial, antiparasitic, insecticidal, repellent, oral and dental, dermatological, nasal and many other effects. The current review highlights the chemical constituents and pharmacological and therapeutic activities of Eucalyptus species grown in Iraq.

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In vitrosusceptibility ofMycobacterium tuberculosisto extracts ofEucalyptus camaldulensisandEucalyptus torellianaand isolated compounds

Cited by 25 publications

References 25 publications

In vitro Anti-mycobacterial activity of selected medicinal plants against Mycobacterium tuberculosis and Mycobacterium bovis Strains

In vitro Anti-mycobacterial activity of selected medicinal plants against Mycobacterium tuberculosis and Mycobacterium bovis Strains

Antimicrobial activity of Eucalyptus camaldulensis Dehn. plant extracts and essential oils: A review

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq

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