In‐vitro DNA binding and antimicrobial studies of trivalent transition metal ion based macrocyclic complexes

Abstract

In the current research work diaminotoluene based tetra-azamacrocyclic-14 membered [N4] macrocylic complexes of nitrate, chloride and acetate trivalent transition metals salts of Cr(III) and Fe(III) have been synthesized by taking the route of template methodology. The synthesized complexes were fully characterized by spectroscopic and physicoanalytical techniques like IR, ESI-MS, ESR, Powder XRD, TGA, UV-visible, magnetic moment, molar conductance, in addition to the elemental analysis measurements. The monomeric and electrolytic nature of the complexes is elucidated by the help of ESI-MS and molar conductance values that reveals about the 1:2 electrolytic behaviour. On the basis of above analytical techniques the complexes may be empirically formulated as [MLX]X2 in which L is macrocyclic ligand obtained from the [2+2] condensation reaction of 3,4-diaminotoluene (DAT) and dibenzoylmethane (DBM). The thermal data provides an indication towards the absence of water molecular and various decomposition steps in the complexes. Further the compounds were screened for their antimicrobial potency against few strains of bacteria and fungus and fair results were found from the above studies. In addition to these DNA binding activity was also performed in order to elucidate the mode of binding the newly synthesised complexes.

Transition metallo-curcumin complexes: a new hope for endometriosis?

“…To explore the toxicity of complexes, a hemolytic assay was performed with slight modifications. 52 Fresh blood was collected, the red blood cells (RBCs) were separated and washed with phosphate buffer saline (PBS), pH 7.4, five times. The different concentrations of complexes were then incubated with RBC suspensions at 37 1C for 60 minutes.…”

“…Our findings are consistent with an earlier report where macrocyclic complexes of Ni exhibited toxicity towards RBCs at very high concentrations. 52 Thus, conjugation with transition metal ions (except Ni at high concentration) does not seem to alter the hemocompatible nature of the Curc molecule and can be regarded as safe for potential therapeutic use.…”

Antibacterial, DNA photocleavage and molecular docking studies of newly prepared Schiff-based macrocyclic complexes

“…This emphasizes how important macrocyclic scaffolds are for supporting several vital biological processes, including respiration. 5,6 Because of their special qualities and possible uses, heteroatom-containing macrocyclic Schiff-based complexes are a prominent family of molecules in the field of coordination chemistry. The durability and adaptability of supramolecular complexes make them significant.…”

“…Their capacity to interact with metal ions and their distinct macrocyclic structure make them useful instruments for creating functional molecules with specific characteristics. 5,6 Because macrocyclic derivatives are distinct in terms of their host-guest chemistry, structure, and behaviors, researchers have been interested in creating new macrocyclic systems. These substances have demonstrated significant promise in a wide range of applications, such as chemical sensors, catalysts, therapeutic agents, agents for magnetic resonance imaging (MRI), and numerous other biomedical uses.…”

Synthesis, spectroscopic elucidation, density functional theory calculation, and molecular docking studies of a novel series of tetradentate macrocyclic Schiff base ligands and their Zn(II) complexes and investigations of their antimicrobial, anti‐inflammatory, and anticancer activities

“…20,21 The research field dealing with Schiff base macrocyclic compounds is very broad, due in part to their potential interest in a number of interdisciplinary areas that include bioinorganic chemistry, 22 catalysis, 23,24 and magnetochemistry. 25,26 A number of important macrocyclic molecules that show biological activities including antibacterial, 27,28 antifungal, 29,30 antioxidant, 31 antitumor, 32 DNA binding, 33 and anticancer activities 34 have been reported. Because of the wide-range applications of Schiff base macrocyclic compounds, scientists extensively investigate transition metal complexes derived from Schiff base macrocyclic ligands.…”