In vitro degradation behavior of a hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair

Abstract

A poly(glycolide) (PGA) fiber-reinforced hydroxyapatite/poly(lactide-co-glycolide) (HA/PLGA) composite with high mechanical strength has been prepared previously.

Spatiotemporal Magnetocaloric Microenvironment for Guiding the Fate of Biodegradable Polymer Implants

“…As shown in Figure 3f, the M w of PLGA in all scaffolds decreased exponentially along with the degradation time, which was consistent with the reported results. [ 3,5,18 ] During the whole degradation process, the M w decrease of PLGA in the IO‐OA/PLGA scaffolds under AMF+ was the fastest, especially after degradation for 4 weeks. At 16th week, the M w of PLGA in PLGA, IO/PLGA, and IO‐OA/PLGA scaffolds under AMF+ (under AMF‐) decreased from about 250 KDa to 47.63 ± 0.75 (40.40 ± 1.44), 32.26 ± 6.68 (46.14 ± 4.12), and 23.52 ± 0.04 (38.92 ± 0.35) KDa, respectively.…”

“…It has been reported that the hydrolysis of PLGA in the degradation medium proceeds in three stages. [ 5,18 ] In the first stage, the molecular weight decreases rapidly with low mass loss. In the second stage, severe mass loss begins along with monomer formation, but the change of molecular weight decreases.…”

“…[ 2,3 ] Additionally, it is an important feature that the degradation rate of the implant materials should match the tissue growth rate (close or slightly lower than the bone reconstruction rate). [ 4,5 ] During the process of tissue growth, the ideal implant materials should maintain their mechanical properties and structural integrity for sufficient time, and then rapidly degrade, leaving enough space for newly‐formed tissue. [ 5–7 ] Unfortunately, an implant that is required to remain intact for months would probably take years to totally degrade, which often leads to the development of chronic inflammation or the formation of sinus at the implanted area, affecting the quality of bone healing.…”

“…[ 7,12,13 ] However, the complex physiological environment (e.g., blood flow velocity, giant cells, degrading enzymes, and so on) makes the degradation behavior of PLGA unpredictable after implantation. [ 5,14 ] Although the change of surrounding environment, such as adding acid‐base catalysts or hydrolase, could also be utilized to study the degradation behavior of materials in vitro, the internal environment is relatively stable and difficult to control in real‐time. [ 15,16 ] Therefore, it is urgent to develop an effective method to spatiotemporally regulate the degradation of PLGA implants to fit the healing status of bone tissue.…”

Electroactive Composite of FeCl3‐Doped P3HT/PLGA with Adjustable Electrical Conductivity for Potential Application in Neural Tissue Engineering

“…The degradation products of PLGA can be absorbed and metabolized by the human body, which can minimize the potential physical interference in nerve regeneration. Those composites of effective electrical activity and biocompatibility have been widely used in tissue engineering repair research …”