Abstract:Volumetric muscle loss (VML) is the traumatic loss of skeletal muscle resulting in damage that overwhelms the body's capacity for self‐repair, leading to functional impairment. Thus, the need for technologies that promote regeneration of skeletal muscle fibers to integrate with remaining muscle architecture is imperative. Our lab has developed scaffoldless, tissue‐engineered skeletal muscle units (SMUs) for VML treatment in sheep. Additionally, in order to ensure proper innervation of the SMU myofibers, we dev… Show more
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