<i>In vitro</i> antibiotic susceptibility patterns of <i>Propionibacterium acnes</i> isolated from acne patients: an Egyptian university hospital‐based study

Fattah, Nermeen S. A. Abdel; Darwish, Yasser W.

doi:10.1111/jdv.12057

Cited by 38 publications

(27 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally speaking, the resistant cases mainly involved MLS B antibiotics. This high frequency of ML resistance of P. acnes in Chinese patients is consistent with the common picture throughout the world, yet the resistance rate is lower than that of the majority of western countries . This may be explained by the widespread application of macrolides (e.g.…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

Multicenter cross‐sectional observational study of antibiotic resistance and the genotypes of Propionibacterium acnes isolated from Chinese patients with acne vulgaris

Fan

Fei

Wang

et al. 2015

The Journal of Dermatology

View full text Add to dashboard Cite

Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of Propionibacterium acnes. This cross-sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in P. acnes, investigating the measures of acne management in China and analyzing the genotypes of antibiotic-resistant strains of P. acnes. Altogether, 312 strains of P. acnes were collected from patients in five medical centers across central China after reviewing the corresponding medical history in detail. The samples underwent antibiotic susceptibility assays by agar dilution method with a total of 11 classes of antibiotics being tested. The antibiotic-resistant strains were screened and further analyzed by investigation of the genotypes regarding 23S rRNA, 16S rRNA and erm(X). The predominant resistance occurred in macrolides and lincomycin with an overall resistance rate of 47.8%. The resistance to tetracyclines was scarce with only two cases identified. The emergence of minimum inhibitory concentration elevation for tetracyclines is associated with its application history (P < 0.005). The genotypes of the reported macrolide-lincosamide-streptogramin B resistance strains were also spotted in Chinese subjects while other resistance determinants may also exist. The tetracyclines have been proved to be vastly susceptible while macrolides and lincomycin face a serious resistance status in China.

show abstract

Section: Discussionsupporting

confidence: 84%

“…The massive and long‐term application of antibiotics makes us doubt their current potency. Numerous studies conducted throughout the world have shown that P. acnes resistance to antibiotics has become an “elephant in the room” . Nevertheless, antibiotics still remain the first‐line treatment for acne.…”

Section: Discussionmentioning

confidence: 99%

Multicenter cross‐sectional observational study of antibiotic resistance and the genotypes of Propionibacterium acnes isolated from Chinese patients with acne vulgaris

Fan

Fei

Wang

et al. 2015

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Erythromycin and clindamycin are often involved in cases of resistance, and there is frequent cross‐resistance to the two antibiotics . In a 2001 study performed in Singapore (Table ), these antibiotics showed the greatest percentage of resistant isolates in patients (69.2% and 50%, respectively) followed by co‐trimoxazole (38.5%) and doxycycline (23%) .…”

Section: Resultsmentioning

confidence: 99%

“…Antibiotic resistance in P. acnes is a global public health concern (Table ), and the prevalence of the problem has increased from 20% in 1978 to 62% in 1996 . The highest rates of resistance observed are against clindamycin and erythromycin …”

Section: Resultsmentioning

confidence: 99%

South‐East Asia study alliance guidelines on the management of acne vulgaris in South‐East Asian patients

Goh

Abad-Casintahan

et al. 2015

The Journal of Dermatology

View full text Add to dashboard Cite

The management of acne in South-East Asia is unique, as Asian skin and local variables require a clinical approach unlike that utilized in other parts of the world. There are different treatment guidelines per country in the region, and a group of leading dermatologists from these countries convened to review these guidelines, discuss current practices and recent advances, and formulate consensus guidelines to harmonize the management of acne vulgaris in the region. Emphasis has been placed on formulating recommendations to impede the development of antibiotic resistance in Propionibacterium acnes. The group adopted the Acne Consensus Conference system for grading acne severity. The group recommends that patients may be treated with topical medications including retinoids, benzoyl peroxide (BPO), salicylic acid, a combination of retinoid and BPO, or a combination of retinoids and BPO with or without antibiotics for mild acne; topical retinoid with topical BPO and a oral antibiotic for moderate acne; and oral isotretinoin if the patient fails first-line treatment (a 6-or 8-week trial of combined oral antibiotics and topical retinoids with BPO) for severe acne. Maintenance acne treatment using topical retinoids with or without BPO is recommended. To prevent the development of antibiotic resistance, topical antibiotics should not be used as monotherapy or used simultaneously with oral antibiotics. Skin care, comprised of cleansing, moisturizing and sun protection, is likewise recommended. Patient education and good communication is recommended to improve adherence, and advice should be given about the characteristics of the skin care products patients should use.

show abstract

“…Topical and oral antibiotics are commonly used to treat acne (Gollnick et al, ; Thiboutot et al, ). Antibiotic resistance is, however, increasing, and resistance to topical macrolides reported in over 50% of P. acnes strains in many countries has decreased their effectiveness (Abdel Fattah & Darwish, ; Dreno et al, ; Gollnick et al, ; Nakase, Nakaminami, Noguchi, Nishijima, & Sasatsu, ; Nast et al, ; World Health Organization, ). Moreover, damage to stable skin microbiomes and the antibiotic resistance of nontarget bacteria as a cause of the proliferation of opportunistic pathogens are major concerns, especially in cases of Staphylococcus aureus and Methicillin‐resistant Staphylococcus aureus (Levy, Huang, Roling, Leyden, & Margolis, ; Mills Jr, Thornsberry, Cardin, Smiles, & Leyden, ; Nakase et al, ).…”

Section: Introductionmentioning

confidence: 99%

The potential of probiotics for treating acne vulgaris: A review of literature on acne and microbiota

Goodarzi

Mozafarpoor

Bodaghabadi

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Acne is known as a chronic inflammatory skin disease with sever adverse effects on quality of life in the patients. The increasing resistance to antibiotics has decreased their effectiveness in treating acne. As viable microbial dietary supplements, probiotics provide health benefits through fighting pathogens and maintaining the homeostasis of the gut and skin microbiome. The present article reviewed the potential of probiotics as beneficial microorganisms for treating acne vulgaris. This review of literature was conducted through a bibliographic search of popular databases, including Science Direct, PubMed, Scielo and Medline, using keywords such as probiotics, prebiotics, synbiotics, microbiome, and acne vulgaris to determine potential applications of these beneficial microbiomes in treating acne vulgaris. Acne lesions are associated with increases in proportion of Propionibacterium acnes as a skin commensal bacterium. The environmental studies showed inhibitory effects of probiotics on P. acnes, mediating by antibacterial proteins and bacteriocin‐like inhibitory substances, and their immunomodulatory effects onkeratinocytes and epithelial cells. Probiotics were also found to inhibit cytokine IL‐8 in epithelial cells and keratinocytes, suggesting immunomodulatory activities. Moreover, glycerol fermentation by Staphylococcus epidermidis was found to be a natural skin defense against acne and an overgrowth inhibitor of P. acnes. As an antimicrobial agent in lotions and cosmetic formulations, Lactococcus sp. can decrease the inflammatory mediators that are produced by P. acnes and cause vasodilation, edema, mast cell degranulation and TNF‐alpha release. Oral administration of probiotics was found to constitute an adjuvant therapy to conventional modalities for treating mild‐to‐moderate acne vulgaris.

show abstract

In vitro antibiotic susceptibility patterns of Propionibacterium acnes isolated from acne patients: an Egyptian university hospital‐based study

Abstract: Propionibacterium acnes in vitro susceptibility patterns differed among Egyptian patients to the commonly prescribed antibiotics with the highest to lowest resistance to clindamycin, erythromycin, oxytetracycline, doxycycline and azithromycin.

Cited by 38 publications

References 24 publications

Multicenter cross‐sectional observational study of antibiotic resistance and the genotypes of Propionibacterium acnes isolated from Chinese patients with acne vulgaris

Multicenter cross‐sectional observational study of antibiotic resistance and the genotypes of Propionibacterium acnes isolated from Chinese patients with acne vulgaris

South‐East Asia study alliance guidelines on the management of acne vulgaris in South‐East Asian patients

The potential of probiotics for treating acne vulgaris: A review of literature on acne and microbiota

Contact Info

Product

Resources

About