<i>In Vitro</i> and <i>in Vivo</i> Biological Investigations of Camphene and Its Mechanism Insights: A Review

Hachlafi, Naoufal El; Aanniz, Tariq; Menyiy, Naoual El; Baaboua, Aicha El; Omari, Nasreddine El; Balahbib, Abdelaali; Shariati, Mohammad Ali; Zengin, Gökhan; Fikri-Benbrahim, Kawtar; Bouyahya, Abdelhakim

doi:10.1080/87559129.2021.1936007

Cited by 62 publications

(47 citation statements)

References 88 publications

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“…Therefore, researchers have been searching for alternatives to conventional antibiotics. Within this context, natural substances, particularly those extracted from medicinal plants, constitute a source of drugs against various pathologies, including diabetes, cancer, inflammation, and pathologies linked to stress and microbial infections [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The antibacterial activity of these natural products is linked to different mechanisms of action, such as the increase in membrane permeability, the decrease in membrane integrity, and the disruption of efflux pumps [ 10 , 13 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Within this context, natural substances, particularly those extracted from medicinal plants, constitute a source of drugs against various pathologies, including diabetes, cancer, inflammation, and pathologies linked to stress and microbial infections [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. The antibacterial activity of these natural products is linked to different mechanisms of action, such as the increase in membrane permeability, the decrease in membrane integrity, and the disruption of efflux pumps [ 10 , 13 , 18 , 19 ]. However, the efficacy of these compounds is not significant for therapeutical applications, because some pathogenic strains continue to induce the problem of resistance, which, until recently, remained unrecognized.…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

et al. 2022

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Bacterial strains have developed an ability to resist antibiotics via numerous mechanisms. Recently, researchers conducted several studies to identify natural bioactive compounds, particularly secondary metabolites of medicinal plants, such as terpenoids, flavonoids, and phenolic acids, as antibacterial agents. These molecules exert several mechanisms of action at different structural, cellular, and molecular levels, which could make them candidates or lead compounds for developing natural antibiotics. Research findings revealed that these bioactive compounds can inhibit the synthesis of DNA and proteins, block oxidative respiration, increase membrane permeability, and decrease membrane integrity. Furthermore, recent investigations showed that some bacterial strains resist these different mechanisms of antibacterial agents. Researchers demonstrated that this resistance to antibiotics is linked to a microbial cell-to-cell communication system called quorum sensing (QS). Consequently, inhibition of QS or quorum quenching is a promising strategy to not only overcome the resistance problems but also to treat infections. In this respect, various bioactive molecules, including terpenoids, flavonoids, and phenolic acids, exhibit numerous anti-QS mechanisms via the inhibition of auto-inducer releases, sequestration of QS-mediated molecules, and deregulation of QS gene expression. However, clinical applications of these molecules have not been fully covered, which limits their use against infectious diseases. Accordingly, the aim of the present work was to discuss the role of the QS system in bacteria and its involvement in virulence and resistance to antibiotics. In addition, the present review summarizes the most recent and relevant literature pertaining to the anti-quorum sensing of secondary metabolites and its relationship to antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

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“…While isoamyl alcohol is known to induce morphological changes in yeast ( 24 , 25 ), phenylethyl alcohol serves as an antifungal agent ( 26 ) and might have additional morphogenic functions during the fungal life cycle, as shown in the yeast Candida albicans ( 27 ). Both α-pinene and d -limonene are known microbial volatiles with antimicrobial properties ( 9 , 16 , 28 ) and serve as communication signals in other termite species ( 29 , 30 ), while camphene is reported to have antioxidant activities ( 31 ). Only a few of the detected chemical features were deduced to be of anthropogenic or unknown origin (e.g., 2-ethylhexyl salicylate, cyclohexane, and trichloromethane) ( 29 ).…”

Section: Resultsmentioning

confidence: 99%

Comparative Genomic and Metabolomic Analysis of Termitomyces Species Provides Insights into the Terpenome of the Fungal Cultivar and the Characteristic Odor of the Fungus Garden of Macrotermes natalensis Termites

et al. 2022

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The symbiosis between macrotermitinae termites and Termitomyces is obligate for both partners and is one of the most important contributors to biomass conversion in the Old World tropic’s ecosystems. To date, research efforts have dominantly focused on acquiring a better understanding of the degradative capabilities of Termitomyces to sustain the obligate nutritional symbiosis, but our knowledge of the small-molecule repertoire of the fungal cultivar mediating interspecies and interkingdom interactions has remained fragmented.

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“…Similar to several other bioactives which showed promising anticancer properties [ 87 , 88 , 89 , 90 , 91 , 92 , 93 ], carvone has also been studied for its anticancer properties. Indeed, several in vitro investigations based on cell culture tests showed that this compound exhibits antiproliferative effects against various cancer cell lines.…”

Section: Resultsmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Carvone

et al. 2021

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Carvone is a monoterpene ketone contained in the essential oils of several aromatic and medicinal plants of the Lamiaceae and Asteraceae families. From aromatic plants, this monoterpene is secreted at different concentrations depending on the species, the parts used, and the extraction methods. Currently, pharmacological investigations showed that carvone exhibits multiple pharmacological properties such as antibacterial, antifungal, antiparasitic, antineuraminidase, antioxidant, anti-inflammatory, and anticancer activities. These studies were carried out in vitro and in vivo and involved a great deal of knowledge on the mechanisms of action. Indeed, the antimicrobial effects are related to the action of carvone on the cell membrane and to ultrastructural changes, while the anti-inflammatory, antidiabetic, and anticancer effects involve the action on cellular and molecular targets such as inducing of apoptosis, autophagy, and senescence. With its multiple mechanisms, carvone can be considered as natural compounds to develop therapeutic drugs. However, other investigations regarding its precise mechanisms of action as well as its acute and chronic toxicities are needed to validate its applications. Therefore, this review discusses the principal studies investigating the pharmacological properties of carvone, and the mechanism of action underlying some of these properties. Moreover, further investigations of major pharmacodynamic and pharmacokinetic studies were also suggested.

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In Vitro and in Vivo Biological Investigations of Camphene and Its Mechanism Insights: A Review

Cited by 62 publications

References 88 publications

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

Comparative Genomic and Metabolomic Analysis of Termitomyces Species Provides Insights into the Terpenome of the Fungal Cultivar and the Characteristic Odor of the Fungus Garden of Macrotermes natalensis Termites

Health Benefits and Pharmacological Properties of Carvone

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