In Vitro and In Vivo Antiallergic Effects of Glycyrrhiza glabra and Its Components

Shin, Yong-Wook; Bae, Eun‐Ah; Lee, Bomi; Lee, Seung Ho; Kim, Jeong Ah; Kim, Yeong-Shik; Kim, Dong-Hyun

doi:10.1055/s-2007-967126

Cited by 123 publications

(72 citation statements)

References 29 publications

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“…1,2 Pharmacological studies and clinical practice have demonstrated that OTS extracted from this plant exhibited many biological functions, including hepatoprotective, 3,4 antioxidative, 5 anticarcinogenic, 6 antiallergic, 7 and antiviral activities. 8 It is also widely used as a flavorin additive in the food industry due to its sweet taste.…”

mentioning

confidence: 99%

Structural characterization and identification of oleanane‐type triterpene saponins in Glycyrrhiza uralensis Fischer by rapid‐resolution liquid chromatography coupled with time‐of‐flight mass spectrometry

Zheng

Zhou

et al. 2010

Rapid Comm Mass Spectrometry

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Oleanane-type triterpene saponins (OTS) are major active ingredients in Glycyrrhiza uralensis. In this work, a rapid-resolution liquid chromatography with time-of-flight mass spectrometry (RRLC/TOF-MS) method has been developed to characterize and identify OTS from G. uralensis. The major diagnostic ions and fragmentation pathways from thirteen OTS have been characterized for the first time. At a low fragmentor voltage of 120 V in positive ion mode, the precursor ion [M + H](+) or/and [M + Na](+) was obtained for accurate determination of molecular formula. When the fragmentor voltage was increased to 425 V, abundant characteristic fragment ions were observed for structural characterization. Neutral losses of sugar moieties, such as glucuronic acid (GlcA, 176 Da), glucose (Glc, 162 Da) and rhamnose (Rha, 146 Da), were commonly observed in the MS spectra for prediction of the sugar number and sequences. Other typical losses included AcOH (60 Da), CH(2)O (30 Da), 2 × H(2)O (2 × 18 Da) and HCOOH (46 Da) from [Aglycone + H-H(2)O](+) (named [B](+)), corresponding to the presence of a C(22)-acetyl group, C(24)-hydroxyl group, C(22)-hydroxyl group or C(30)-carboxyl group on the aglycone moiety, respectively. In particular, characteristic ring cleavages of the aglycone moieties on A- and B-rings were observed. Based on the fragmentation patterns of reference compounds, nineteen OTS have been identified in an extract of G. uralensis, thirteen of which were unambiguously identified and the other six were tentatively assigned.

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mentioning

confidence: 99%

Structural characterization and identification of oleanane‐type triterpene saponins in Glycyrrhiza uralensis Fischer by rapid‐resolution liquid chromatography coupled with time‐of‐flight mass spectrometry

Zheng

Zhou

et al. 2010

Rapid Comm Mass Spectrometry

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“…It is reported that glycyrrhizin, liquiritin apioside and liquiritin have the significant activity of relieving cough and inhibiting allergic asthma (Kamei et al, 2005;Jayaprakasam et al, 2009;Xie et al, 2009;Shin et al, 2007). Their content decreases significantly after roasting with honey (Sung and Li, 2004;Wang et al, 1995;Wang et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Influence of Honey-Roasting on the Main Pharmacological Activities and the Water-Soluble Active Glycosides of Licorice

Wang

Zhang²,

Tang³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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In traditional Chinese medicine (TCM), licorice is usually processed with honey and traditionally used in decoction form. However, the influence of honey-roasting on the main pharmacological activities and the water-soluble active constituents of licorice has not been reported. The aim of the present study is to determine whether honey-roasting can modify the main pharmacological activities and the active constituents of licorice. According to licorice clinical application and processing method, the mainly related pharmacological activities of crude licorice, processed licorice and refined honey, such as enhancing immune function, relieving cough, eliminating phlegm and detoxication, were compared. The results showed that honey-roasting obviously reinforced the licorice activity of enhancing Pi-deficiency mice's immune function, and significantly weaken the licorice activity of relieving cough, removing phlegm and detoxication. However, honey didn't show the significant activity of relieving cough, removing phlegm and detoxication. The influence of honey-roasting on the chemical compositions in licorice slice and licorice decoction was investigated by using HPLC. The results showed that the content and the decocting quantity of mainly 5 active glycosides in licorice, i.e. liquiritin apioside, liquiritin, licuraside, isoliquiritin and glycyrrhizin, obviously changed after processing; glycyrrhizin and liquiritin obviously decomposed during honey-roasting. In conclusion, honey-roasting obviously modified the main pharmacological activities and the water-soluble compositions of licorice. The modification was not cause by honey only. This finding may shed some light on understanding the differences in the therapeutic values of crude and processed licorice.

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“…These results indicate that glycyrrhizin interfere the production of IgE by decreasing the IgE-stimulating cytokines. not liquiritigenin reduces the level of IgE in serum [293]. Flavonoids extracted from licorice root quench LPS-induced pulmonary inflammation by inhibiting the recruitment of neutrophils, macrophages and lymphocytes in BALF, and suppressing the mRNA expression of TNF and IL-1β in LPS-challenged lung tissue in mice [238].…”

Section: Licorice Root (Glycyrrhiza Glabra)mentioning

confidence: 97%

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Pundir¹,

Kulka²

2013

Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

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In Vitro and In Vivo Antiallergic Effects of Glycyrrhiza glabra and Its Components

Cited by 123 publications

References 29 publications

Structural characterization and identification of oleanane‐type triterpene saponins in Glycyrrhiza uralensis Fischer by rapid‐resolution liquid chromatography coupled with time‐of‐flight mass spectrometry

Structural characterization and identification of oleanane‐type triterpene saponins in Glycyrrhiza uralensis Fischer by rapid‐resolution liquid chromatography coupled with time‐of‐flight mass spectrometry

Influence of Honey-Roasting on the Main Pharmacological Activities and the Water-Soluble Active Glycosides of Licorice

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

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