In vitro &amp; in silico study of hypoglycemic potential of Pterocarpus marsupium heartwood extract

Yadav, Vivek Kumar; Mishra, Abha

doi:10.1080/14786419.2018.1471078

Cited by 14 publications

(9 citation statements)

References 14 publications

(5 reference statements)

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“…Acarbose, a common α-glucosidase inhibitors was used as the positive control in this study. At a concentration of 50 ppm, acarbose showed inhibition of 85.1% and it possessed an IC 50 of 4.29 μg/mL, comparable to the value reported by Yadav [11]. However, in general, IC 50 values for acarbose have been found to be dependent on the materials and method employed and it differs from one study to another.…”

Section: Ic 50 Value Of Acarbosesupporting

confidence: 73%

In-Vitro Î±-Glucosidase Inhibitory Activities of Muntingia Calabura Linn.

Azman¹,

Hashim²,

Ahmad³

2019

IJET

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Muntingia calabura Linn. also known locally as “ceri kampung” is a plant of the family Elaeocarpaceae. The plant has been reported to possess several medicinal properties including reducing high blood pressure, lowering cholesterol level and controlling Type 2 diabetes. Type 2 diabetes is usually related to postprandial hyperglycemia, which is related to the rise of blood sugar level after a meal. This condition can be controlled by α-glucosidase inhibitors which inhibit the enzyme from catalyzing the liberation of glucose from carbohydrates in the digestive tract. Despite many biological studies reported for the plant, its antidiabetic potential has not been widely explored. Thus the aim of this study was to find potential α-glucosidase inhibitors from 16 extracts of M. calabura as a therapeutic approach in decreasing postprandial hyperglycemia. The hexane (Hx), ethyl acetate (Ea), 75% ethanol (Et) and aqueous (Aq) extracts of four parts (fruit, leaf, stem and root) of M. calabura (collected from Bangi, Selangor) were screened for their a-glucosidase inhibitory activities at 50.00, 25.00, 12.50, 6.25, 3.13, 1.56 and 0.78 ppm prepared via two-fold serial dilution against the positive control, acarbose. The aqueous leaf (AqL) and root extracts (AqR) exhibited very strong activities with IC50 values of 0.15 and 0.41 µg/ml while the other extracts showed strong to moderately strong activities with IC50 values ranging from 1.83-11.66 µg/ml against acarbose (4.3 µg/ml).

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Section: Ic 50 Value Of Acarbosesupporting

confidence: 73%

In-Vitro Î±-Glucosidase Inhibitory Activities of Muntingia Calabura Linn.

Azman¹,

Hashim²,

Ahmad³

2019

IJET

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“…Meanwhile, driven by market demand among other interests [9], it is also common to label wood with similar anatomical features (red color) as a precious wood species such as those from Pterocarpus when in fact it might originate from a different genus or even family [9,10]. Owing to the rarity and value of rosewood tree species, research on Pterocarpus has mainly focused on the value of developing species for timber production [11][12][13], the proper identification of precious wood [9,10], and the introduction and cultivation for use in timber plantations [14][15][16]. Given the issues of overexploitation and illegal logging associated with high value timber such as rosewood, having molecular markers for species and population identification can be very useful in identifying imposter woods, and tracking illegal logging and exportation [17].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analyses of Five Complete Chloroplast Genomes from the Genus Pterocarpus (Fabacaeae)

Hong

Zhao

et al. 2020

IJMS

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Pterocarpus is a genus of trees mainly distributed in tropical Asia, Africa, and South America. Some species of Pterocarpus are rosewood tree species, having important economic value for timber, and for some species, medicinal value as well. Up to now, information about this genus with regard to the genomic characteristics of the chloroplasts has been limited. Based on a combination of next-generation sequencing (Illumina Hiseq) and long-read sequencing (PacBio), the whole chloroplast genomes (cp genomes) of five species (rosewoods) in Pterocarpus (Pterocarpus macrocarpus, P. santalinus, P. indicus, P. pedatus, P. marsupium) have been assembled. The cp genomes of five species in Pterocarpus have similar structural characteristics, gene content, and sequence to other flowering plants. The cp genomes have a typical four-part structure, containing 110 unique genes (77 protein coding genes, 4 rRNAs, 29 tRNAs). Through comparative genomic analysis, abundant simple sequence repeat (SSR)loci (333–349) were detected in Pterocarpus, among which A /T single nucleotide repeats accounted for the highest proportion (72.8–76.4%). In the five cp genomes of Pterocarpus, eight hypervariable regions, including trnH-GUG_psbA, trnS-UGA_psbC, accD-psaI, ndhI-exon2_ndhI-exon1, ndhG_ndhi-exon2, rpoC2-exon2, ccsA, and trnfM-CAU, are proposed for use as DNA barcode regions. In the comparison of gene selection pressures (P. santalinus as the reference genome), purifying selection was inferred as the primary mode of selection in maintaining important biological functions. Phylogenetic analysis shows that Pterocarpus is a monophyletic group. The species P. tinctorius is resolved as early diverging in the genus. Pterocarpus was resolved as sister to the genus Tipuana.

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“…In DPPH scavenging activity and ABTS•+ scavenging activity, IC50 values were found to be 138.3, 12.4, 13.5 and 47.8, 3.9, 4.2μg/mL for aqueous, methanolic extract of P. marsupium and standard ascorbic acid respectively. In α-amylase inhibition assay and α-glucosidase inhibition assay, IC50 values for standard Acarbose, aqueous and methanolic extract of heartwood were 44.09, 166.72, 48.20 and 45.17, 172.32, 48.12 respectively [16]. The effects of different fractions of heart wood of Pterocarpus marsupium on antioxidant enzyme like protein thiols and the efficacy of the extract for the protection of the renal function in alloxan induced diabetic rats was evaluated by Bhata, Nayak [17].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Pterocarpus Marsupium for the Treatment of Diabetes and Other Disorders

Sibi¹

2019

JCMAH

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Pterocarpus marsupium Roxb., is a deciduous tree commonly grows in India and Sri Lanka. It is well known to Ayurvedic medicine because of its curative and lenitive properties. The heartwood extract of P. marsupium is reported to have many pharmacological compounds and used in treatment of various disorders. Literature was collected via electronic search (PubMed, ScienceDirect) from published articles that reports medicinal properties of P. marsupium. A significant research of antidiabetic activities and other medicinal properties of P. marsupium combined with bioactive compounds isolated from the plant will provide leads for the discovery of new drugs for the management of many disorders with minimal side effects.

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In vitro & in silico study of hypoglycemic potential of Pterocarpus marsupium heartwood extract

Cited by 14 publications

References 14 publications

In-Vitro Î±-Glucosidase Inhibitory Activities of Muntingia Calabura Linn.

In-Vitro Î±-Glucosidase Inhibitory Activities of Muntingia Calabura Linn.

Comparative Analyses of Five Complete Chloroplast Genomes from the Genus Pterocarpus (Fabacaeae)

Pterocarpus Marsupium for the Treatment of Diabetes and Other Disorders

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