In situ sensors for flow reactors – a review

Abstract

The integration of specific sensors into microfluidic reactors and devices is crucial for the optimization of controllable variables such as flow, temperature, energy input (light, microwaves etc.). In this review,...

Developing flow photo-thiol–ene functionalizations of cinchona alkaloids with an autonomous self-optimizing flow reactor

“…[66][67][68][69][70] This still emerging technology requires process control instrumentations for automation, in situ monitoring by process analytical technology (PAT) and feedback algorithms to assist chemists in the complex decision-making process. [71][72][73][74][75] Our lab contributed to this field of research with the development of a reconfigurable self-optimizing flow platform which was deployed for natural product synthesis, 76,77 ligand preparation 78 and palladium-catalyzed direct C-H arylation. 79 Capitalizing on our experience in this field and with the aim of demonstrating the capability of our platform to accommodate to photo-mediated thiol-ene reactions, we designed a self-optimizing flow device combining an automatic sample handler, a custom built photochemical reactor and an online HPLC unit (Fig.…”

“…66–70 This still emerging technology requires process control instrumentations for automation, in situ monitoring by process analytical technology (PAT) and feedback algorithms to assist chemists in the complex decision-making process. 71–75 Our lab contributed to this field of research with the development of a reconfigurable self-optimizing flow platform which was deployed for natural product synthesis, 76,77 ligand preparation 78 and palladium-catalyzed direct C–H arylation. 79…”

Chemical Knowledge via In Situ Analytics: Advancing Quality and Sustainability

“…A recent article 30 reviewing PAT methodologies available for monitoring flow reactions explains why. The authors argue: "To free the process from expensive offline sampling, it is essential to integrate innovative analytical techniques capable of exempting transferring samples and manual handling.…”

Revisiting aromatic diazotization and aryl diazonium salts in continuous flow: highlighted research during 2001–2021

“…4B). 48,49 Compared with the traditional off-line detection, in-line, online and at-line detection have features such as time saving, labor saving, avoiding human error, shortening the screening time of conditions, etc. 50 For reactions involving highly unstable chemical species, it is necessary to introduce nondestructive in-line detection equipment with very short acquisition time for real-time monitoring.…”