<i>In situ</i> fabrication of MS@MnO<sub>2</sub> hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy

Zhu, Xufeng; Liu, Yanan; Yuan, Guanglong; Guo, Xian; Cen, Jieqiong; Gong, Youcong; Liu, Jie; Ye, Gang

doi:10.1039/d0nr03931d

Cited by 66 publications

(41 citation statements)

References 39 publications

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“…The same results were obtained from the colorimetric and fluorescent assay, in which MB (Zhu et al, 2020) and TA (Karim et al, 2018) were utilized as the dyes, respectively (Figures 3C,D). The discoloration of MB and the decrease in fluorescence intensity of TAOH produced via the oxidation of TA by •OH both indicated the ROS-scavenging activity of SeCQDs.…”

Section: The Ros-scavenging Activity Of Secqdssupporting

confidence: 71%

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

Zhou

Wang

et al. 2021

Front. Pharmacol.

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Multi-target intervention and synergistic treatment are critical for the drug development of Alzheimer’s disease (AD) due to its complex and multifactional nature. Oxidative stress and amyloid β peptides (Aβ) accumulation have been recognized as therapeutic targets for AD. Herein, with ability to inhibit Aβ aggregation and the broad-spectrum antioxidant properties, the large amino acid mimicking selenium-doped carbon quantum dots (SeCQDs) are presented as novel nanoagents for multi-target therapy of AD. Compared with the precursor, selenocystine, SeCQDs which maintain the intrinsic properties of both selenium and carbon quantum dots (CQDs) possess good biocompatibility and a remarkable ROS-scavenging activity. Moreover, the functionalized α-carboxyl and amino groups on edge of SeCQDs can trigger multivalent interactions with Aβ, leading to the ability of SeCQDs to inhibit Aβ aggregation. In vivo study demonstrated that SeCQDs can significantly ameliorate the Aβ induced memory deficits, reduce Aβ accumulation and inhibit neuron degeneration in AD model rats. The versatility of functionalization and potential ability to cross the blood-brain barrier (BBB) make SeCQDs as prospective nanodrugs for treating AD.

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Section: The Ros-scavenging Activity Of Secqdssupporting

confidence: 71%

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

Zhou

Wang

et al. 2021

Front. Pharmacol.

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“…ROS levels is one of the main mechanisms that kill tumor cells [ 44 , 45 ], and the same phenomenon has been found in PDT [ 46 , 47 ]. After silencing the expression of GRP78, we also detected the ROS levels.…”

Section: Discussionmentioning

confidence: 76%

Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway

Zuo

Zhong

et al. 2021

ABBS

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Photodynamic therapy (PDT), which is a new method for treating tumors, has been used in the treatment of cancer. In-depth research has shown that PDT cannot completely kill tumor cells, indicating that tumor cells are resistant to PDT. Glucose regulatory protein 78 (GRP78), which is a key regulator of endoplasmic reticulum stress, has been confirmed to be related to tumor resistance and recurrence, but there are relatively few studies on the further mechanism of GRP78 in PDT. Our experiment aimed to observe the role of GRP78 in HOS human osteosarcoma cells treated with pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPα-PDT) and to explore the possible mechanism by which the silencing of GRP78 expression enhances the sensitivity of HOS osteosarcoma cells to MPPα-PDT. HOS osteosarcoma cells were transfected with siRNA-GRP78. Apoptosis and reactive oxygen species (ROS) levels were detected by Hoechst staining and flow cytometry, cell viability was detected by Cell Counting Kit-8 assay, GRP78 protein fluorescence intensity was detected by immunofluorescence, and apoptosis-related proteins, cell proliferation-related proteins, and Wnt pathway-related proteins were detected by western blot. The results showed that MPPα-PDT can induce HOS cell apoptosis and increase GRP78 expression. After successful siRNA-GRP78 transfection, HOS cell proliferation was decreased, and apoptosis-related proteins expressions was increased, Wnt/β-catenin-related proteins expressions was decreased, and ROS levels was increased. In summary, siRNA-GRP78 enhances the sensitivity of HOS cells to MPPα-PDT, the mechanism may be related to inhibiting Wnt pathway activation and increasing ROS levels.

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“…Similarly, the NPs that formed with the mesoporous Silica nanoparticle (MSN) core and a MnO 2 shell, then loaded with the photosensitizer indocyanine green (ICG) and coated with PEG NPs by Liu's group showed enhanced therapeutic effects. [ 53 ]…”

Section: Different Kinds Of Nanomaterials‐based Nanoplatforms For Cdtmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Jiang

et al. 2021

Adv Funct Materials

264

158

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Triggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non-exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H 2 O 2 ) into the lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor-specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H 2 O 2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo-, ultrasound-, magnetic-, and other stimuli-response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti-cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial-based chemodynamic cancer therapy. In this review, the various nanomaterials-based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better-quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications.

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In situ fabrication of MS@MnO₂ hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy

Abstract: Rreactive oxygen species (ROS) mediated anti-cancer therapy hold the advantages of tumor specificity, high curative effect, and low toxic side effects, which shows powerful potential for cancer treatment.However, hypoxia in...

Cited by 66 publications

References 39 publications

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

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In situ fabrication of MS@MnO2 hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy

Abstract: Rreactive oxygen species (ROS) mediated anti-cancer therapy hold the advantages of tumor specificity, high curative effect, and low toxic side effects, which shows powerful potential for cancer treatment.However, hypoxia in...

Cited by 66 publications

References 39 publications

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-&alpha; methyl ester-mediated photodynamic therapy via the Wnt/&beta;-catenin signaling pathway

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

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In situ fabrication of MS@MnO₂ hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy

Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway