<i>In Silico</i>Modeling of Angiogenesis at Multiple Scales: From Nanoscale to Organ System

Qutub, Amina A.; Gabhann, Feilim Mac; Karagiannis, Emmanouil D.; Popel, Aleksander S.

doi:10.1002/9780470579831.ch10

Cited by 3 publications

(1 citation statement)

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“…Coordination of many cells (both endothelial and parenchymal) during sprouting makes it an ideal candidate for discrete models where objects (individual cells in this case) in an environment are modelled individually, with cell behaviours defined by differential equations or logic‐based rules ( e.g ., agent‐based models, ABM) . These models explicitly represent time and space, as well as the associated evolution of properties and behaviours associated with objects .…”

Section: Systems Biology Approaches To Understand the Multi‐step Procmentioning

confidence: 99%

A systems biology view of blood vessel growth and remodelling

Logsdon

Finley

Popel

et al. 2013

J Cellular Molecular Medi

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136

106

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Blood travels throughout the body in an extensive network of vessels – arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels – arterioles, venules and capillaries – can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi-step morphogenic process of angiogenesis – the sprouting of new blood vessels – and the stability of vascular networks in vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high-throughput experimentation to the angiogenesis process.

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Section: Systems Biology Approaches To Understand the Multi‐step Procmentioning

confidence: 99%