<i>Helicobacter pylori</i> infection and extragastric diseases in 2017

Korwin, Jean-Dominique de; Ianiro, Gianluca; Gibiino, Giulia; Gasbarrini, Antonio

doi:10.1111/hel.12411

Cited by 57 publications

(43 citation statements)

References 73 publications

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“…Although the evidence is not conclusive, chronic H. pylori infection has been also associated with inflammatory bowel diseases, asthma and other allergic manifestations, as well as a variety of other extra-gastrointestinal conditions, including cardiovascular, hematologic and metabolic diseases [9].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, there has been growing scientific interest in the association between H. pylori infection and NAFLD in man [9,10]. Indeed, several observational studies have examined the association between H. pylori infection and risk of NAFLD in middle-aged individuals who were largely asymptomatic for peptic ulcers or functional dyspepsia, and who did not take H. pylori eradication therapy [11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Association between Helicobacter pylori infection and risk of nonalcoholic fatty liver disease: An updated meta-analysis

et al. 2019

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Background: Recent studies that have examined the association between Helicobacter pylori infection and risk of nonalcoholic fatty liver disease (NAFLD) have produced conflicting data. We have performed a systematic review and meta-analysis to assess the association between H. pylori infection and risk of NAFLD. Methods: We searched PubMed, Web of Science and Scopus databases using predefined keywords to identify observational studies (published up to November 2018), in which NAFLD was diagnosed by histology, imaging or biochemistry. Data from selected studies were extracted and meta-analysis was performed using random-effects modeling. The statistical heterogeneity among studies (I 2-index), subgroup analyses and the possibility of publication bias were assessed. Results: Thirteen observational (11 cross-sectional/case-control and 2 longitudinal) studies involving a total of 81,162 middle-aged individuals of predominantly Asian ethnicity (47.5% of whom had H. pylori infection diagnosed by urea breath test, faecal or serological tests) were included in the final analysis. Meta-analysis of data from crosssectional and case-control studies showed that H. pylori infection was associated with increased risk of prevalent NAFLD (n=11 studies; random-effects odds ratio [OR] 1.20, 95%CI 1.07-1.35; I 2 =59.6%); this risk remained significant in those studies where analysis was fully adjusted for age, sex, smoking, adiposity measures, diabetes or dyslipidemia (random-effects OR 1.19, 95% CI 1.07-1.32, I 2 = 0%). Meta-analysis of data from longitudinal studies showed that H. pylori infection was also associated with increased NAFLD incidence (n=2 studies; random-effects hazard ratio 1.14, 95%CI 1.05-1.23; I 2 =0%). Sensitivity analyses did not alter these findings. Funnel plot did not reveal significant publication bias. Conclusions: H. pylori infection is associated with mildly increased risk of both prevalent and incident NAFLD in middle-aged individuals. More prospective studies, particularly in non-Asian populations, and mechanistic studies are required to better elucidate the link between chronic H. pylori infection and NAFLD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and risk of nonalcoholic fatty liver disease: An updated meta-analysis

et al. 2019

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“…Through various mechanisms, such as the release of molecular mimicry, inflammatory mediators, and systemic immune response, H. pylori infection can directly or indirectly impair reproductive functions. [51] Before considering reproductive disorders as another manifestation of extra-digestive diseases related to H. pylori infection, it is significant to carry out further studies about the prevalence of H. pylori infection in patients and controls, and particularly to perform study evaluating reproductive potential after H. pylori infection. [50] Furthermore, biologic researches to explain the relationship between H. pylori infection and infertility are required.…”

Section: Helicobacter Pylori Infection and Infertilitymentioning

confidence: 99%

Infection and Infertility

Wu¹,

Tang²,

Gu³

et al. 2016

Genital Infections and Infertility

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Infection is a multifactorial process, which can be induced by a virus, bacterium, or parasite. It may cause many diseases, including obesity, cancer, and infertility. In this chapter, we focus our attention on the association of infection and fertility alteration. Numerous studies have suggested that genetic polymorphisms influencing infection are associated with infertility. So we also review the genetic influence on infection and risk of infertility.

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“…pylori est une bactérie Gram négatif, de forme hélicoï-dale, pourvoyeuse d'ulcères gastro-duodénaux, via son uréase conduisant à la formation d'ammoniac, toxique pour les cellules épithéliales gastriques. Cette bactérie peut également générer une gastrite atrophique, source d'hypo-ou d'achlorhydrie, et responsable d'une carence en vitamine B12 par diminution des capacités d'absorption intestinale de cette vitamine (et du fer) [5].…”

Section: Commentaireunclassified